1351279-85-0Relevant articles and documents
Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors
Dong, Xiaowu,Zhou, Xinglu,Jing, Hui,Chen, Jianzhong,Liu, Tao,Yang, Bo,He, Qiaojun,Hu, Yongzhou
experimental part, p. 5949 - 5958 (2012/02/01)
A total of 24 well-defined PKB/Akt1 inhibitors were used to generate pharmacophore models applying Catalyst/HypoGen program. The best ranked model (Hypo-1) was then validated by cost analysis, prediction capability, Cat-Scramble and receiver operating cha