132246-40-3Relevant academic research and scientific papers
Pharmacophore identification, virtual screening and biological evaluation of prenylated flavonoids derivatives as PKB/Akt1 inhibitors
Dong, Xiaowu,Zhou, Xinglu,Jing, Hui,Chen, Jianzhong,Liu, Tao,Yang, Bo,He, Qiaojun,Hu, Yongzhou
, p. 5949 - 5958 (2012/02/01)
A total of 24 well-defined PKB/Akt1 inhibitors were used to generate pharmacophore models applying Catalyst/HypoGen program. The best ranked model (Hypo-1) was then validated by cost analysis, prediction capability, Cat-Scramble and receiver operating cha
A facile synthesis of 6-C-prenylflavanones
Bu,Zhao,Li
, p. 1246 - 1248 (2007/10/03)
The first total synthesis of two natural 6-C-prenylflavanones, (±)-6-C-prenyleriodoctyol (1) and 6-C-prenylnaringenin (2), using the acetophenone derivative 6 as the key intermediate is described. This new efficient synthetic approach was mainly based on
STRUCTURE OF 6- OR 8-ISOPRENOID SUBTITUTED FLAVANONE: CHEMICAL SHIFT OF THE HYDROGEN-BONDED HYDROXYL GROUP
Fukai, Toshio,Nomura, Taro
, p. 1861 - 1872 (2007/10/02)
The proton signal of the hydrogen-bonded hydroxyl group of the 6-isoprenoid substituted flavanone was shifted more downfield than that of 6-nonsubstituted flavanone.By comparison of the chemical shifts of the hydrogen-bonded hydroxyl groups of 8-(3",3"-di
