1351585-99-3Relevant academic research and scientific papers
BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
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, (2016/02/10)
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid p
BIODEGRADABLE LIPIDS FOR THE DELIVERY OF ACTIVE AGENTS
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, (2013/06/27)
The present invention relates to a cationic lipid having one or more biodegradable groups located in a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
