1351665-18-3

Basic information

• Product Name: 2-(4-nitrophenyl)-4-phenylpyrimidine
• Synonyms: 2-(4-nitrophenyl)-4-phenylpyrimidine
• CAS NO: 1351665-18-3
• Molecular Weight: 277.282
• Mol File: 1351665-18-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-(4-nitrophenyl)-4-phenylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-nitrophenyl)-4-phenylpyrimidine(1351665-18-3)
• EPA Substance Registry System: 2-(4-nitrophenyl)-4-phenylpyrimidine(1351665-18-3)

Safety Data

• Hazardous Substances Data: 1351665-18-3(Hazardous Substances Data)

Upstream product

• 15723-90-7 4-nitrobenzamidine hydrochloride 
• 100-52-7 benzaldehyde 
• 121-44-8 triethylamine 
• 93-55-0 1-phenyl-propan-1-one 
• 300-57-2 allylbenzene 
• 13036-50-5 2-chloro-4-phenylpyrimidine 
• 24067-17-2 4-nitrophenylboronic acid 
• 98-80-6 phenylboronic acid 

Downstream Products

• 1335148-40-7 C₂₃H₁₆ClN₃O 
• 1351665-19-4 4-(4-phenylpyrimidin-2-yl)aniline 

Relevant articles and documents

Transition Metal Free Intermolecular Direct Oxidative C-N Bond Formation to Polysubstituted Pyrimidines Using Molecular Oxygen as the Sole Oxidant

Various polysubstituted pyrimidines are smoothly formed via a base-promoted intermolecular oxidation C-N bond formation of allylic C(sp3)-H and vinylic C(sp2)-H of allyllic compounds with amidines using O2 as the sole oxid

Synthesis method of pyrimidine compound containing alkyl and aryl

The invention discloses a synthesis method of a pyrimidine compound containing alkyl and aryl, and belongs to the technical field of organic synthesis. Key points of the technical scheme of the invention are as follows: the synthesis method of the pyrimidine compound containing alkyl and aryl comprises the following specific steps: dissolving an aldehyde compound, an amidine hydrochloride compoundand a tertiary aliphatic amine compound in a solvent, adding an iodine reagent and an oxidant, and carrying out a reaction process at 110-150 DEG C to prepare the pyrimidine compound containing alkyland aryl as a target product. The synthesis process is simple and efficient, the pyrimidine compound is directly prepared by one step through a one-pot cascade reaction without transition metal catalysis so that resource waste and environmental pollution caused by use of various reagents in multi-step reaction, purification treatment of reaction intermediates in each step and the like are avoided, the synthesis process is convenient to operate, the raw materials are simple, the reaction conditions are mild, the substrate application range is wide, and meanwhile, alkyl substituents are ingeniously introduced by taking the tertiary fatty amine compound as the raw material.

Iron Catalysis for Modular Pyrimidine Synthesis through β-Ammoniation/Cyclization of Saturated Carbonyl Compounds with Amidines

An efficient method for the modular synthesis of various pyrimidine derivatives by means of the reactions of ketones, aldehydes, or esters with amidines in the presence of an in situ prepared recyclable iron(II)-complex was developed. This operationally simple reaction proceeded with broad functional group tolerance in a regioselective manner via a remarkable unactivated β-C-H bond functionalization. Control experiments were performed to gain deep understanding of the mechanism, and the reactions are likely to proceed through a designed TEMPO complexation/enamine addition/transient α-occupation/β-TEMPO elimination/cyclization sequence.