135182-01-3

Basic information

• Product Name: N-Benzyl-2-(3,4-dimethoxy-phenyl)-N-ethyl-acetamide
• Synonyms: N-Benzyl-2-(3,4-dimethoxy-phenyl)-N-ethyl-acetamide
• CAS NO: 135182-01-3
• Molecular Weight: 313.397
• Mol File: 135182-01-3.mol

Chemical Properties

• CAS DataBase Reference: N-Benzyl-2-(3,4-dimethoxy-phenyl)-N-ethyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-2-(3,4-dimethoxy-phenyl)-N-ethyl-acetamide(135182-01-3)
• EPA Substance Registry System: N-Benzyl-2-(3,4-dimethoxy-phenyl)-N-ethyl-acetamide(135182-01-3)

Safety Data

• Hazardous Substances Data: 135182-01-3(Hazardous Substances Data)

Upstream product

• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 100-52-7 benzaldehyde 
• 75-04-7 ethylamine 

Downstream Products

• 135182-09-1 4-(3,4-Dimethoxy-phenyl)-2-ethyl-1,4-dihydro-2H-isoquinolin-3-one 
• 151250-70-3 Acetic acid (benzyl-ethyl-carbamoyl)-(3,4-dimethoxy-phenyl)-methyl ester 

Relevant articles and documents

A new synthesis of N-substituted-1,2,3,4-tetrahydro-4-phenylisoquinolin-3-ones

1,2,3,4-Tetrahydro-4-phenylisoquinolin-3-ones 3 are obtained from appropriate N,N-disubstituted phenylacetamides 1, using lead tetraacetate (LTA) as oxidant and Lewis or proton acids as cyclizing agents. The methods for this conversion could be one stage (method B or C), or two stages (method A). The latter method was particularly developed to explain the mechanism of the reaction.

Synthesis of 4-aryl-1,4-dihydro-3(2H)-isoquinolinones by oxidative cyclization of N-benzylaraylacetamides

4-Aryl-1,4-dihydro-3(2H)-isoquinolinones are obtained by oxidative cyclization of N-benzyl-N-alkylarylacetamides with lead tetraacetate in acetic acid/trifluoroacetic acid.