135206-85-8

Basic information

• Product Name: 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone
• Synonyms: 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone
• CAS NO: 135206-85-8
• Molecular Weight: 186.158
• Mol File: 135206-85-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone(135206-85-8)
• EPA Substance Registry System: 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone(135206-85-8)

Safety Data

• Hazardous Substances Data: 135206-85-8(Hazardous Substances Data)

Upstream product

• 372-18-9 1,3-Difluorobenzene 
• 139358-54-6 (S)-2-acetoxy-2',4'-difluoropropiophenone 
• 148505-34-4 Acetic acid 2-(2,4-difluoro-phenyl)-1-methyl-2-oxo-ethyl ester 
• 138311-20-3 2-(2,4-difluorophenyl)-2-methoxy-3-methyloxirane 
• 135206-83-6 2-bromo-1-(2,4-difluorophenyl)-1-propanone 

Downstream Products

• 132563-81-6 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one 

Relevant articles and documents

Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess.

Decomposition of α-hydroxyaryl ketones and characterization of some unusual products

α-Hydroxyaryl ketones such as 2-hydroxypropiophenone and 1-(2,4- difluorophenyl)-2-hydroxy-1-propanone, the key intermediates in the preparation of antifungal agents, decompose into oxidized, rearranged, and condensed products. These products were isolated and characterized. The possible mechanisms for the formation of the products are discussed.