139358-54-6

Basic information

• Product Name: 1-Propanone, 2-(acetyloxy)-1-(2,4-difluorophenyl)-, (S)-
• CAS NO: 139358-54-6
• Molecular Formula: C11H10F2O3
• Molecular Weight: 228.195
• Mol File: 139358-54-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 2-(acetyloxy)-1-(2,4-difluorophenyl)-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 2-(acetyloxy)-1-(2,4-difluorophenyl)-, (S)-(139358-54-6)
• EPA Substance Registry System: 1-Propanone, 2-(acetyloxy)-1-(2,4-difluorophenyl)-, (S)-(139358-54-6)

Safety Data

• Hazardous Substances Data: 139358-54-6(Hazardous Substances Data)

Upstream product

• 535-17-1 (S)-2-acetoxypropionic acid 
• 148505-34-4 Acetic acid 2-(2,4-difluoro-phenyl)-1-methyl-2-oxo-ethyl ester 
• 372-18-9 1,3-Difluorobenzene 
• 36394-75-9 (S)-2-acetoxypropanoyl chloride 

Downstream Products

• 135206-85-8 1-(2,4-difluorophenyl)-2-hydroxy-1-propanone 
• 148505-34-4 Acetic acid 2-(2,4-difluoro-phenyl)-1-methyl-2-oxo-ethyl ester 

Relevant articles and documents

Simple chemoenzymatic access to enantiopure pharmacologically interesting (R)-2-hydroxypropiophenones

A chemoenzymatic synthesis of pharmacological interesting (R)-2-hydroxypropiophenones starting from propiophenone derivatives is described. Manganese(III) acetate-mediated acetoxylation followed by fungus-mediated hydrolysis of propiophenone derivatives affords (R)-2-hydroxypropiophenones in high enantiomeric excess.

Triazole antifungals. III. Stereocontrolled synthesis of an optically active triazolylmethyloxirane precursor to antifungal oxazolidine derivatives

Stereocontrolled synthesis of an optically active triazolylmethyloxirane 2, an important intermediate for the preparation of antifungal oxazolidine compounds 1, was achieved by two methods using L-lactic acid as a starting material. The key intermediate ketone 6 used in the procedures also served for the synthesis of the enantiomer of 2 and the corresponding diastereomeric epoxide.