132563-81-6

Basic information

• Product Name: 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one
• Synonyms: 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one
• CAS NO: 132563-81-6
• Molecular Weight: 270.276
• Mol File: 132563-81-6.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one(132563-81-6)
• EPA Substance Registry System: 1-(2,4-difluorophenyl)-2-(tetrahydropyranyloxy)propan-1-one(132563-81-6)

Safety Data

• Hazardous Substances Data: 132563-81-6(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 24057-28-1 pyridinium p-toluenesulfonate 
• 126918-14-7 (2S)-2',4'-Difluoro-2-hydroxypropiophenone 
• 126918-16-9 (R)-1-(2,4-difluorophenyl)-2-hydroxypropan-1-one 
• 348-57-2 2,4-difluorobromobenzene 
• 135270-08-5 4-[(2R)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)-propionyl]morpholine 
• 144025-04-7 (2,4-difluorophenyl)magnesium bromide 
• 126918-15-8 (S)-2-(p-toluenesulfonyloxy)-2',4'-difluoropropiophenone 
• 161457-74-5 (R)-2-(tert-Butyl-dimethyl-silanyloxy)-1-(2,4-difluoro-phenyl)-propan-1-one 
• 161457-73-4 (R)-1-(2,4-Difluoro-phenyl)-2-trimethylsilanyloxy-propan-1-one 
• 148505-34-4 Acetic acid 2-(2,4-difluoro-phenyl)-1-methyl-2-oxo-ethyl ester 
• 138311-20-3 2-(2,4-difluorophenyl)-2-methoxy-3-methyloxirane 
• 135206-83-6 2-bromo-1-(2,4-difluorophenyl)-1-propanone 
• 372-18-9 1,3-Difluorobenzene 

Downstream Products

• 126918-32-9 (2S)-3-(2,4-Difluorophenyl)-3-buten-2-ol 
• 210562-49-5 (2R,3R)-2-(2,4-difluorophenyl)-3-(piperazin-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1266605-65-5 C₂₅H₂₈F₂N₆O 
• 1266605-67-7 C₂₅H₂₇F₃N₆O 
• 1266605-69-9 C₂₅H₂₇ClF₂N₆O 
• 1266605-73-5 (2R,3R)-2-(2,4-difluorophenyl)-3-[4-(5-fluoro-1H-indol-3-ylmethyl)-piperazin-1-yl]-1-(1H-1,2,4-triazol-1-yl)butan-2-ol 
• 1266605-75-7 C₂₅H₂₇ClF₂N₆O 
• 1266605-76-8 C₂₅H₂₇BrF₂N₆O 
• 1266605-77-9 C₂₆H₃₀F₂N₆O 
• 1266605-79-1 C₂₅H₂₇F₂N₇O₃ 
• 1266605-80-4 C₂₆H₃₀F₂N₆O₂ 
• 1266605-81-5 C₂₅H₂₇F₂N₉O 
• 1266605-82-6 C₂₆H₂₇F₂N₇O 
• 1266605-83-7 C₂₆H₂₉F₂N₇O₂ 

Relevant articles and documents

Preparations of antifungal Sch 42427/SM 9164: Preparative chromatographic resolution, and total asymmetric synthesis via enzymatic preparation of chiral α-hydroxy arylketones

Efficient approaches towards the preparation of chiral azole antifungals Sch 42427/SM 9164 (1) via large scale chromatographic separation of its enantiomers, or via enzymatic syntheses of key chiral intermediates α-hydroxy arylketones 5 in excellent enantiomeric excesses (ees) are described.

Triazole alcohol derivative as well as preparation method and application thereof

The invention relates to a triazole alcohol derivative as well as a preparation method and application thereof. The chemical structure of the triazole alcohol derivative is shown as a formula I, R1 represents a benzene ring or a substituted benzene ring, and substituent groups of the substituted benzene ring can be located at all positions of the benzene ring, can be mono-substituted or multi-substituted, and can be selected from a) halogen which is F and Cl; b) an electron withdrawing group which is cyano or trifluoromethyl; c ) a lower alkyl of 1-4 carbon atoms or a halogen substituted loweralkyl; and d) lower alkoxy of 1-4 carbon atoms or halogen substituted lower alkoxy. The compound of the invention has strong antifungal activity, has the advantages of low toxicity, wide antibacterial spectrum and the like, and can be used for preparing antifungal drugs.

A preparation method of the midbody sets up lucky Kang Zuo (by machine translation)

The invention relates to the field of pharmaceutical technology, in particular to a method of preparing intermediates of sets up lucky Kang Zuo, comprising the following steps: D, L - methyl lactate, morpholine, 3, 4 - methoxychroman reaction, with 2, 4 - difluoro bromobenzene reagent reaction to obtain compound III format; compound III in the catalyst under the catalysis of the B L - menthol and triphenylphosphine, by the asymmetric kohl Chaikefusiji reaction to obtain the chiral compound IV; compound IV with 1, 2, 4 - triazole reaction, and then removing the water Cheng Huan, get sets up lucky Kang Zuo key intermediate compound V, this invention uses the D, L - lactic acid methyl ester, by adding the catalyst induction to generate chiral center, greatly reducing the reaction of the raw material cost, high yield, high purity, easy controlled, is suitable for industrial production. (by machine translation)