1352152-68-1

Upstream product

• 29632-82-4 5-bromo-1,1-dioxo-1,2-dihydro-1λ6-benzo[d]isothiazol-3-one 
• 139937-37-4 5-bromo-2-toluenesulfonyl chloride 
• 591-17-3 meta-bromotoluene 
• 1607838-25-4 5-bromo-2-(tert-butyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide 
• 1261758-91-1 C₇H₇Br₂NO₂S 
• 116340-67-1 4-bromo-2-methyl-benzenesulfonamide 

Downstream Products

• 1607838-28-7 8-[2-[bis-(4-methoxybenzyl)amino]-3-chloro-5-(2-ethyl-1,1-dioxo-2,3-dihydro-1H-benzo[d]isothiazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one 
• 1254319-63-5 5-bromo-2-(methyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide 
• 1352152-67-0 N-α-({1-[(tert-butoxycarbonyl)amino]cyclohexyl}carbonyl)-4-(1,1-dioxo-2,3-dihydro-1,2-benzisothiazol-5-yl)-L-phenylalaninamide 

Relevant academic research and scientific papers

BICYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS

Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.

NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE

A compound of Formula I is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The 5 invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also 10 relates to a process for manufacturing compounds of Formula I.

PYRIDYL PIPERIDINES

The invention provides novel substituted pyridyl piperidine compounds according to Formula (I) which are Wnt pathway inhibitors, their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

N-(2-CYANO HETEROCYCLYL)PYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

Provided are compounds of Formula I, a JAK inhibitor, and use thereof for the treatment of JAK-mediated diseases by the application.

GEMINALLY SUBSTITUTED CYANOETHYLPYRAZOLO PYRIDONES AS JANUS KINASE INHIBITORS

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

2-AMINOPYRIDINE COMPOUNDS

The invention provides novel substituted 2-aminopyridine compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases such as cancer, inflammatory or degenerative diseases.

MST1 KINASE INHIBITORS AND METHODS OF THEIR USE

Compounds for the inhibition of mammalian Ste20-like kinase 1 (MST1) are disclosed, along with compositions comprising them and methods of their use in the treatment, management or prevention of an inflammatory or autoimmune diseases or disorders.