29632-82-4

Usage

Uses

Used in Paint Industry:
1,2-Benzisothiazol-3(2H)-one, 5-bromo, 1,1-dioxide is used as a biocide and preservative in the paint industry to prevent the growth of microorganisms that can cause spoilage and deterioration of the paint. Its antimicrobial properties help maintain the quality and longevity of the paint products.
Used in Cleaning Agents:
In the cleaning agents industry, 1,2-Benzisothiazol-3(2H)-one, 5-bromo, 1,1-dioxide is used as an antimicrobial additive to enhance the effectiveness of cleaning products. It helps in controlling the growth of bacteria, fungi, and other microorganisms, ensuring a cleaner and more hygienic environment.
Used in Consumer Products:
1,2-Benzisothiazol-3(2H)-one, 5-bromo, 1,1-dioxide is also used in various consumer products, such as personal care products and household cleaning products, as a preservative to prevent microbial contamination. Its broad-spectrum antimicrobial activity helps maintain the safety and efficacy of these products.

InChI:InChI=1/C7H4BrNO3S/c8-4-1-2-6-5(3-4)7(10)9-13(6,11)12/h1-3H,(H,9,10)

Upstream product

• 116340-67-1 4-bromo-2-methyl-benzenesulfonamide 
• 52727-57-8 5-bromo-2-aminobenzoic acid methyl ester 
• 736948-72-4 methyl 5-bromo-2-(chlorosulfonyl)benzoate 
• 591-17-3 meta-bromotoluene 
• 139937-37-4 5-bromo-2-toluenesulfonyl chloride 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 29632-80-2 5-bromo-3,3-difluoro-3H-benzo[c][1,2]oxathiole 1,1-dioxide 

Downstream Products

• 1352152-68-1 5-bromo-2,3-dihydro-benzo[d]isothiazole 1,1-dioxide 
• 29083-17-8 5-methoxysaccharin 
• 1254319-63-5 5-bromo-2-(methyl)-2,3-dihydrobenzo[d]isothiazole 1,1-dioxide 

Relevant academic research and scientific papers

Preparation method and medical application of benzisothiazole and benzothiophene

The invention discloses a preparation method and medical application of benzisothiazole and benzothiophene, and telates to the field of pharmaceutical chemistry. According to the invention, benzisothiazole and benzothiophene are the first type of HIF-2 agonists; compared with a compound M1001 found by the applicant in the earlier stage, the invention has better HIF-2 agonist activity, and has remarkable enhancement activity on expression of mRNA and protein of EPO, VGEF, Glut1, NDRG1 and the like at the downstream of HIF-2, so that the invention can be used for preparing drugs for treating and/or preventing chronic kidney diseases/chronic renal anemia, dyslipidemia and high cholesterol caused by abnormal expression of HIF-2; and the method has a good industrialization prospect.

INHIBITORS OF THE YAP/TAZ-TEAD INTERACTION AND THEIR USE IN THE TREATMENT OF CANCER

The invention relates to compounds of formula (I): wherein R1; R2, R3, R4, R5 and are as defined in the description. The compounds of formula (I) are inhibitors of the YAP/TAZ-TEAD interaction and thu

Novel compounds that are inhibitors of YAP/TAZ-TEAD interaction and their use in the treatment of malignant mesothelioma

These compounds are useful as inhibitors of the YAP/TAZ-TEAD interaction.

BICYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS

Provided herein are compounds, compositions including them, and methods of modulating GPR120 activity and treating diseases mediated by GPR120 by administering such compounds and compositions.

NOVEL 3-INDOL SUBSTITUTED DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR USE

A compound of Formula I is provided: or pharmaceutically acceptable enantiomers, salts or solvates thereof. The 5 invention further relates to the use of the compounds of Formula I as TDO2 inhibitors. The invention also relates to the use of the compounds of Formula I for the treatment and/or prevention of cancer, neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and Huntington's disease, chronic viral infections such as HCV and HIV, depression, and obesity. The invention also 10 relates to a process for manufacturing compounds of Formula I.

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Oxidative cyclization of N-alkyl-o-methyl-arenesulfonamides to biologically important saccharin derivatives

Various biologically important saccharin skeletons and their N-alkyl derivatives have been efficiently prepared by chromium(VI) oxide catalyzed H5IO6 oxidation of N-alkyl-o-methyl-arenesulfonamides in acetonitrile. N-tert-Butyl saccharin skeletons were easily prepared by H5IO6-CrO3 oxidation of N-tert-butyl-o-methyl arenesulfonamides in the presence of acetic anhydride. The method that furnished the novel fluoro and trifluoromethyl substituted saccharin skeletons is characterized by two steps, a simple work-up procedure, a single purification and good overall yields from substituted toluene derivatives.