135216-72-7Relevant academic research and scientific papers
Visible Light-Promoted Aliphatic C-H Arylation Using Selectfluor as a Hydrogen Atom Transfer Reagent
Zhao, Hong,Jin, Jian
, p. 6179 - 6184 (2019)
A mild, practical method for direct arylation of unactivated C(sp3)-H bonds with heteroarenes has been achieved via photochemistry. Selectfluor is used as a hydrogen atom transfer reagent under visible light irradiation. A diverse range of chem
Scalable Photoelectrochemical Dehydrogenative Cross-Coupling of Heteroarenes with Aliphatic C?H Bonds
Chen, Peng-Yu,Xu, Hai-Chao,Xu, Pin
supporting information, p. 14275 - 14280 (2020/07/13)
Heteroarenes are structural motifs found in many bioactive compounds and functional materials. Dehydrogenative cross-coupling of heteroarenes with aliphatic C?H bonds provides straightforward access to functionalized heteroarenes from readily available materials. Established methods employ stoichiometric chemical oxidants under conditions of heating or light irradiation. By merging electrochemistry and photochemistry, we have achieved efficient photoelectrochemical dehydrogenative cross-coupling of heteroarenes and C(sp3)?H donors through H2 evolution, without the addition of metal catalysts or chemical oxidants. Mechanistically, the C(sp3)?H donor is converted to a nucleophilic carbon radical through H-atom transfer with chlorine atom, which is produced by light irradiation of anodically generated Cl2 from Cl?. The carbon radical then undergoes radical substitution to the heteroarene to afford alkylated heteroarene products.
Green oxidant H2O2 as a hydrogen atom transfer reagent for visible light-mediated Minisci reaction
Zhao, Hong,Li, Zhenlong,Jin, Jian
supporting information, p. 12533 - 12537 (2019/08/21)
A visible light-mediated "green" protocol for metal-free oxidative coupling of heteroarenes and aliphatic C-H components has been achieved via a radical pathway. This cross-dehydrogenative coupling method features a broad scope of substrates. The green ox
Homolytic Alkylations of Substituted Pyridazines
Samaritoni, Jack G.,Babbitt, George
, p. 583 - 587 (2007/10/02)
The unsymmetrically substituted pyridazines 1 (X = Ph, CH3) have been found to undergo homolytic heteroaromatic alkylation in moderate to good yields with high regioselectivity.The site of substitution was established by conversion to 5 and measurement of
