1352307-99-3

Upstream product

• 320742-78-7 (2R)-N-methyl-N-[(3S,5S)-dimethyl-6-(tert-butyldiphenylsilyloxy)-hex-1-yl]-2-methylbutyramide 
• 320742-82-3 (R)-N,2-dimethyl-N-((3S,5S,6R)-3,5,6-trimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)octyl)butanamide 
• 320742-81-2 (R)-N-((3S,5S,E)-3,5-dimethyl-8-oxo-8-((R)-2-oxo-4-phenyloxazolidin-3-yl)oct-6-en-1-yl)-N,2-dimethylbutanamide 
• 320742-77-6 (R)-N-((3S,5S)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexyl)-2-methylbutanamide 
• 320742-74-3 Methanesulfonic acid (3S,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexyl ester 
• 320742-75-4 (2S,4S)-6-azido-2,4-dimethyl-1-(tert-butyldiphenylsilyloxy)hexane 
• 320742-76-5 (3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexylamine 
• 320742-83-4 (2'R,3R,4S,6S)-3,4,6-trimethyl-8-[methyl-2'-(methylbutyryl)amino]octanoic acid 
• 320742-79-8 (2R)-N-methyl-N-((3S,5S)-3,5-dimethyl-6-hydroxy-hex-1-yl)-2-methylbutyramide 
• 320742-80-1 N-(3,5-dimethyl-6-oxo-hexyl)-2,N-dimethyl-butyramide 
• 123444-68-8 (S)-4-(tert-butyldiphenylsilyloxy)-3-methylbutanal 
• 128329-63-5 (3S,5S)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexan-1-ol 
• 32231-50-8 (R)-2-methylbutyric acid 
• 1351186-13-4 (R)-3-((3S,5S)-6-(tert-butyldiphenylsilyloxy)-3,5-dimethylhexanoyl)-4-phenyloxazolidin-2-one 

Relevant academic research and scientific papers

Synthesis and biological activity of kalkitoxin and its analogues

Total syntheses of kalkitoxin, isolated from the Caribbean Lyngbya majuscula, and its analogues, 3-epi-, 7-epi-, 8-epi-, 10-epi-, 10-nor-, and 16-nor-kalkitoxin, were achieved via oxazolidinone-based diastereoselective 1,4-addition reaction of a methyl group and efficient TiCl4-mediated thiazoline ring formation as the key steps. The biological activities of synthetic kalkitoxin and its analogues were evaluated with brine shrimp.