1352344-90-1

Basic information

• Product Name: C₂₉H₃₇FN₂O₅
• Synonyms: C₂₉H₃₇FN₂O₅
• CAS NO: 1352344-90-1
• Molecular Weight: 512.622
• Mol File: 1352344-90-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₇FN₂O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₇FN₂O₅(1352344-90-1)
• EPA Substance Registry System: C₂₉H₃₇FN₂O₅(1352344-90-1)

Safety Data

• Hazardous Substances Data: 1352344-90-1(Hazardous Substances Data)

Upstream product

• 905710-66-9 4-bromo-3-(hydroxymethyl)benzonitrile 
• 254744-14-4 2-bromo-5-cyanobenzyl acetate 
• 1352344-84-3 C₁₃H₁₄BrNO₂ 
• 1352344-85-4 C₁₉H₂₆BNO₄ 
• 1352344-88-7 C₂₃H₃₇FN₂O₄ 
• 1352344-86-5 C₁₆H₂₀FNO₃ 
• 1352344-87-6 C₁₆H₂₄FNO₃ 
• 24424-99-5 di-tert-butyl dicarbonate 
• 41963-20-6 4-bromo-3-methylbenzonirtile 
• 124045-51-8 N-t-butoxycarbonyl-N-methylpropargylamine 
• 190197-86-5 4-bromo-3-(bromomethyl)benzonitrile 

Downstream Products

• 144025-14-9 (+)-Desmethylcitalopram 
• 128196-01-0 escitalopram 

Relevant articles and documents

Enantioenriched synthesis of Escitalopram using lithiation-borylation methodology

The asymmetric synthesis of Escitalopram has been completed using a lithiation-borylation reaction as the key step. Suitably functionalized enantioenriched carbamate (er 98:2) and boronic ester coupling partners were prepared and following deprotonation with s-BuLi and borylation, the tertiary alcohol was obtained in 42% yield and 93:7 er. The lithiation-borylation reaction was found to tolerate nitrile, benzylic alcohol and N-Boc functionalities. The tertiary alcohol was converted to Escitalopram in three further steps.