135245-91-9

Upstream product

• 138513-53-8 (R)-(E)-2-<<(tert-Butyldimethylsilyl)oxy>methyl>-5-methylhex-3-en-1-ol 
• 226926-94-9 Acetic acid (E)-(R)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5-methyl-hex-3-enyl ester 
• 138513-54-9 (R)-(E)-2-<<(Benzyloxy)methoxy>methyl>-1-<(tert-butyldimethylsilyl)oxy>-5-methylhex-3-ene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 3587-60-8 Benzyloxymethyl chloride 
• 917-54-4 methyllithium 
• 133377-92-1 (R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-propionaldehyde 

Downstream Products

• 135218-66-5 (2S,3R)-2-Benzyloxymethoxymethyl-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol 
• 135218-70-1 (2S,3R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-ethoxymethoxy)-butan-1-ol 
• 135245-92-0 (2R,3R)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-3-(2-methoxy-ethoxymethoxy)-butan-1-ol 
• 135218-67-6 (2R,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-(2-methoxy-ethoxymethoxymethyl)-butan-1-ol 
• 135589-02-5 (2S,3R)-3-(tert-Butyl-diphenyl-silanyloxy)-2-(2-methoxy-ethoxymethoxymethyl)-butan-1-ol 

Relevant academic research and scientific papers

ASYMMETRIZED TRIS (HYDROXYMETHYL)METHANE AS A HIGHLY STEREODIVERGENT CHIRAL BUILDING BLOCK: PREPARATION OF ALL FOUR STEREOISOMERS OF PROTECTED 2-HYDROXYMETHYL-1,3-BUTANEDIOL

Monoacetate 3 is a synthetic equivalent of asymmetrized tris(hydroxymethyl)methane 1, which is a new chiral building block endowed with latent C3v symmetry.Thanks to this property, starting from a single enantiomer 3, it is possible to get not only both (R) and (S) aldehydes 7, but also all the stereoisomers deriving from addition of a C-nucleophile to 7, just relying on a single diastereocontrol (double stereodivergency).