135589-02-5Relevant academic research and scientific papers
ASYMMETRIZED TRIS (HYDROXYMETHYL)METHANE AS A HIGHLY STEREODIVERGENT CHIRAL BUILDING BLOCK: PREPARATION OF ALL FOUR STEREOISOMERS OF PROTECTED 2-HYDROXYMETHYL-1,3-BUTANEDIOL
Guanti, Giuseppe,Banfi, Luca,Narisano, Enrica
, p. 6421 - 6424 (2007/10/02)
Monoacetate 3 is a synthetic equivalent of asymmetrized tris(hydroxymethyl)methane 1, which is a new chiral building block endowed with latent C3v symmetry.Thanks to this property, starting from a single enantiomer 3, it is possible to get not only both (R) and (S) aldehydes 7, but also all the stereoisomers deriving from addition of a C-nucleophile to 7, just relying on a single diastereocontrol (double stereodivergency).
