135253-29-1

Upstream product

• 135253-27-9 (S)-3-<2,2-Bis(methylthio)-1-cyclobutylcarbonyl>-1,3-oxazolidin-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 140710-10-7 cis-2-(tert-butyldiphenylsiloxymethyl)cyclobutan-1-ol 
• 140710-09-4 cis-2-hydroxymethylcyclobutan-1-ol 
• 140710-08-3 2-oxo-3,5-dioxabicyclo<4.2.0>octane-4-spirocyclohexane 
• 135356-00-2 Methyl (S)-2,2-bis(methylthio)cyclobutane-1-carboxylate 
• 135356-01-3 (S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol 
• 140852-30-8 (1S,2S)-2-(tert-butyldiphenylsiloxymethyl)cyclobutan-1-ol 
• 135253-28-0 (S)-<2,2-Bis(methylthio)-1-cyclobutyl>methanol t-butyldiphenylsilyl ether 

Downstream Products

• 135253-30-4 Methyl <(R),(Z)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate 
• 135253-31-5 Methyl <(R),(E)-2-(t-butyldiphenylsiloxy)methyl-1-cyclobutylidene>acetate 
• 135253-39-3 (1R,2R)-2-<2-(t-Butyldiphenylsiloxy)ethyl>-2-methyl-1-cyclobutyl methyl ketone 
• 135253-40-6 tert-Butyl-[2-((1R,2S)-2-isopropenyl-1-methyl-cyclobutyl)-ethoxy]-diphenyl-silane 
• 135253-38-2 1-{(1R,2R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-2-methyl-cyclobutyl}-ethanol 
• 26532-22-9 (1R, 2S)-grandisol 
• 128075-94-5 (R)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}dihydrofuran-2(3H)-one 
• 102717-29-3 (5S)-5-({[tert-butyl(diphenyl)silyl]oxy}methyl)dihydrofuran-2(3H)-one 

Relevant academic research and scientific papers

Enantioselective synthesis of 2-substituted cyclobutanones

(equation presented) An enantioselective synthesis of 2-substituted cyclobutanones has been achieved by sequential application of the titanium-mediated cyclopropanation of α-hydroxy esters and the pinacol-type rearrangement of the resulting α-hydroxycyclo

COMPOUNDS THAT INHIBIT MCL-1 PROTEIN

Provided herein are myeloid cell leukemia 1 protein (Mcl-1) inhibitors, methods of their preparation, related pharmaceutical compositions, and methods of using the same. For example, provided herein are compounds of Formula I, and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing the compounds. The compounds and compositions provided herein may be used, for example, in the treatment of diseases or conditions, such as cancer.

Regio-, stereo-, and enantioselective synthesis of cyclobutanols by means of the photoaddition of 1,3-dioxin-4-ones and lipase-catalyzed acetylation

Homochiral cis-2-hydroxymethylcyclobutanols, their all cis 3-methyl, and 4-hydroxymethyl derivatives were synthesized from 1,3-dioxin-4-ones via cyclobutane ring formation by [2+2]photocycloaddition, dioxanone ring cleavage, and reduction, followed by lip

Enantio- and Diastereo-Selective Synthesis of (+)-Grandisol

(+)-Grandisol, an insect pheromone having cyclobutane skeleton, is synthesized enantio- and diastereoselectively.The key steps in the synthesis are the asymmetric cycloaddition reaction catalyzed by a chiral titanium reagent and the diastereoselective conjugate addition reaction by the combined use of Me2CuLi and trimethylsilyl trifluoromethanesulfonate.