1352653-84-9Relevant academic research and scientific papers
Enantioselective α-benzoyloxylation of ketones promoted by primary amine catalyst
Jadhav, Milind S.,Righi, Paolo,Marcantoni, Enrico,Bencivenni, Giorgio
experimental part, p. 2667 - 2674 (2012/06/01)
A mixture of 9-amino-(9-deoxy)epi-dihydroquinidine and salicylic acid was able to promote the direct reaction of various cyclohexanones with dibenzoyl peroxide, thus affording the corresponding protected α-hydroxy carbonyl compounds in high yield and enantioselectivity. Interestingly the same catalytic salt was found to be active when 1-indanones derivatives were directly employed in the reaction with dibenzoyl peroxide furnishing chiral 1-oxo-2,3-dihydro-1H- inden-2-yl benzoates in high yields and enantioselectivity. Furthermore their treatment with NaBH4 gives easy access to the corresponding enantioenriched 1,2-diols in high yields and without any loss of stereoselectivity.
Direct asymmetric α benzoyloxylation of cyclic ketones
Lifchits, Olga,Demoulin, Nicolas,List, Benjamin
supporting information; experimental part, p. 9680 - 9683 (2011/12/05)
It's amine business: A readily available cinchona-derived primary amine is an effective catalyst for the direct asymmetric α benzoyloxylation of cyclic ketones (see scheme; Bz=benzoyl). This efficient and highly enantioselective method uses inexpensive be
