135266-72-7

Basic information

• Product Name: diethyl {[(1S,12bS)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl]methyl}propanedioate
• Synonyms: Diethyl {[(1S,12bS)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl]methyl}malonate; propanedioic acid, 2-[[(1S,12bS)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl]methyl]-, diethyl ester
• CAS NO: 135266-72-7
• Molecular Formula: C₂₅H₃₄N₂O₄
• Molecular Weight: 426.5485
• EINECS: 603-912-2
• Mol File: 135266-72-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 542.485°C at 760 mmHg
• Flash Point: 281.885°C
• Density: 1.196g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.59
• CAS DataBase Reference: diethyl {[(1S,12bS)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl]methyl}propanedioate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl {[(1S,12bS)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl]methyl}propanedioate(135266-72-7)
• EPA Substance Registry System: diethyl {[(1S,12bS)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl]methyl}propanedioate(135266-72-7)

Safety Data

• Hazardous Substances Data: 135266-72-7(Hazardous Substances Data)

Upstream product

• 135099-82-0 C₂₆H₃₄N₂O₅ 
• 135099-82-0 (+/-)-diethyl 15a-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate 
• 300661-83-0 diethyl 15aS-ethyl-2,3,6,11,15,15a-hexahydro-1H,5H-indolo[2,3-a]pyrano[3,2-i]quinolizine-14,14-(13H)-dicarboxylate 
• 135099-86-4 (1S,12bS)-1-(2,2'-diethoxycarbonyl-2'-hydroxymethyl-ethyl)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine 

Downstream Products

• 6835-99-0 14-epivincamine 
• 42971-09-5 Vinpocetine 
• 4880-92-6 apovincamine 
• 4880-88-0 vinburnine 
• 1617-90-9 vincamin 
• 70474-14-5 (-)-14-imino-eburnan 

Relevant articles and documents

Preparation methods for chiral impurities of vincamine

The invention relates to preparation methods for chiral impurities of vincamine. Through oriented synthesis method and the later column chromatography separation, high purity product of seven chiral impurities can be obtained, and the preparation methods can be used for the qualitative and quantitative analysis of impurities in the production of vincamine, so that the separation and confirmation of the seven chiral impurities in vincamine drugs can be realized, and the drug standard of the vincamine can be enhanced, and therefore, the vincamine with high purity can be obtained. Compared with existing preparation methods for the vincamine, the preparation methods relate to the preparation of seven chiral isomers, and are more complete and simpler in operation.

Synthesis of vinca alkaloids and related compounds. XVI. New route to the stereoselective synthesis of (+)-vincamine, (-)-vincamone and (+)-apovincaminic acid esters

A stereoselective methods has been elaborated for the synthesis of oxime esters, from which, as common intermediates, (+)-apovincaminic acid esters, (+)-vincamine and (-)-vincamone can be prepared.