13528-40-0Relevant academic research and scientific papers
Epoxide hydrolase-catalyzed enantioselective synthesis of chiral 1,2-diols via desymmetrization of meso-epoxides
Zhao, Lishan,Han, Bin,Huang, Zilin,Miller, Mark,Huang, Hongjun,Malashock, Dan S.,Zhu, Zuolin,Milan, Aileen,Robertson, Dan E.,Weiner, David P.,Burk, Mark J.
, p. 11156 - 11157 (2004)
The discovery, from nature, of a diverse set of microbial epoxide hydrolases is reported. The utility of a library of epoxide hydrolases in the synthesis of chiral 1,2-diols via desymmetrization of a wide range of meso-epoxides, including cyclic as well as acyclic alkyl- and aryl-substituted substrates, is demonstrated. The chiral (R,R)-diols were furnished with high ee's and yields. The discovery of the first microbial epoxide hydrolases providing access to complementary (S,S)-diols is also described. Copyright
