135290-20-9

Usage

Uses

Used in Pharmaceutical Industry:
Acetonitrile, (3-fluorophenoxy)(9CI) is used as a solvent in the pharmaceutical industry for the synthesis of various drugs. Its ability to dissolve a broad range of substances makes it a versatile component in the production process of medications.
Used in Agrochemical Industry:
In the agrochemical sector, Acetonitrile, (3-fluorophenoxy)(9CI) serves as a solvent for the formulation of pesticides and other agricultural chemicals, contributing to the efficiency and effectiveness of these products.
Used in Specialty Chemicals Production:
Acetonitrile, (3-fluorophenoxy)(9CI) is utilized as a solvent in the manufacturing of specialty chemicals, which are often used in niche applications requiring specific chemical properties.
Used for Extraction of Fatty Acids:
Acetonitrile, (3-fluorophenoxy)(9CI) is employed as a solvent in the extraction process of fatty acids, which are crucial components in the food industry, cosmetics, and other industrial applications.
Used in Dye Manufacturing:
Acetonitrile, (3-fluorophenoxy)(9CI) is used in the production of dyes, where its solvent properties aid in the creation of vibrant and stable colorants for textiles, printing inks, and other uses.
Used as a Stabilizer in Rubber Production:
In the rubber industry, this chemical acts as a stabilizer, enhancing the durability and performance of rubber products by preventing degradation and maintaining the material's integrity over time.

Upstream product

• 372-20-3 3-fluorophenol 
• 107-14-2 chloroacetonitrile 
• 768-35-4 3-fluorophenylboronic acid 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 1532534-65-8 C₂₀H₂₃FO₄ 
• 1532533-86-0 2-(3-fluorophenoxy)-1-(2,4,6-trihydroxyphenyl)ethanone 
• 1532534-39-6 1-(2,4-dihydroxy-5-propylphenyl)-2-(3-fluorophenoxy)ethanone 
• 1532534-13-6 1-(2,4-dihydroxy-5-methylphenyl)-2-(3-fluorophenoxy)ethanone 
• 1312414-45-1 2-(3-fluorophenoxymethyl)-5-(4-fluorophenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one 
• 1016796-64-7 2-(3-fluorophenoxy)thioacetamide 

Relevant academic research and scientific papers

Synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile

A new and efficient protocol for the synthesis of aryloxyacetonitriles based on arylboronic acids with 2-bromoacetonitrile has been developed using eco-friendly hydrogen peroxide as oxidant under metal-free conditions. This method is compatible with arylboronic acid attached sensitive substituent and obtains desired product in moderate to good yield.

Combinatorial synthesis and in vitro evaluation of a biaryl hydroxyketone library as antivirulence agents against mrsa

Antibiotic resistance coupled with decreased development of new antibiotics necessitates the search for novel antibacterial agents. Antivirulence agents offer an alternative to conventional antibiotics. In this work, we report on a family of small-molecule antivirulence agents against methicillin-resistant Staphylococcus aureus (MRSA), the most widespread bacterial pathogen. Structure-activity relationship studies led to the development of a concise synthesis of a 148-member biarylhydroxyketone library. An acylation bond-forming process afforded resorcinols (1) and aryloxy acetonitriles (2) as synthons. A Lewis-acid-activated Friedel-Crafts' acylation step involving a nitrile functionality of 2 by ZnCl2, followed by nucleophilic attack by 1 was executed to obtain biaryl hydroxyketones in excellent yields. A large number of products crystallized. This strategy affords a range of biarylhydroxyketones in a single step. This is the first collective synthetic study documenting access to this class of compounds through a single synthetic operation. In vitro efficacy of compounds in this library was evaluated by a rabbit erythrocyte hemolysis assay. The most efficacious compound, 4f-12, inhibits hemolysis by 98.1 ± 0.1% compared to control in the absence of the compound.

Heterocyclic compounds as P2X7 ion channel blockers

The present invention relates to a novel series of 4,5-diphenyl-2-amino-4,5-dihydro-imidazole derivatives of the formula II: 1 wherein R, R1, R2, R3, R4, R5, X and Y are as defined herein. This invention also relates to methods of making these compounds. The compounds of this invention are P2X7 ion channel blockers and are therefore useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of diseases having an inflammatory component, including inflammatory bowel disease, rheumatoid arthritis and disease conditions associated with the central nervous system, such as stroke, Alzheimer''s disease, etc.

POLY(ADP-RIBOSE) POLYMERASE INHIBITORS CONSISTING OF PYRIMIDINE DERIVATIVES

A medicament for therapeutic and/or preventive treatment of a brain disease, which comprises a compound represented by the following general formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient: wherein R represents hydrogen atom, a C1-C8 alkyl group, a substituted C1-C8 alkyl group, an aryl group, a substituted aryl group, an aryl(C1-C8)alkyl group and the like; Y represents hydrogen atom or -C(R2)R3 (R2 and R3 represent hydrogen atom, a C1-C8 alkyl group, a C1-C8 alkoxy(C1-C8)alkyl group, a hydroxy(C1-C8)alkyl group and the like); symbol "a" represents single bond when Y represents hydrogen atom, or "a" represents double bound when Y represents -C(R2)R3; -A-B- represents -CH2-CH2-, -S-CH2-, -O-CH2-, -CH2-S-, -CH2-O-, -SO-CH2-, -CH2-SO-, -SO2-CH2-, or -CH2-SO2-; and Z represents -CH2- or single bond.