1352964-91-0Relevant academic research and scientific papers
A neighbouring group effect leading to enhanced nucleophilic substitution of amines at the hindered α-carbon atom of an α-hydroxyphosphonate
Zsuzsa Kiss, Nóra,Kaszás, Anna,Drahos, László,Mucsi, Zoltán,Keglevich, Gy?rgy
, p. 207 - 209 (2012)
Diethyl α-hydroxy-benzylphosphonate undergoes nucleophilic substitution with primary amines of sufficient reactivity at around 100 °C to afford the corresponding α-aminophosphonates. The substitution can be enhanced by microwave irradiation. The reaction
