1352965-91-3Relevant academic research and scientific papers
Ruthenium(II)-Catalyzed Traceless C?H Functionalization Using an N?N Bond as an Internal Oxidant
Zhou, Shuguang,Wang, Jinhu,Chen, Pei,Chen, Kehao,Zhu, Jin
supporting information, p. 14508 - 14512 (2016/10/03)
A previously elusive RuII-catalyzed N?N bond-based traceless C?H functionalization strategy is reported. An N-amino (i.e., hydrazine) group is used for the directed C?H functionalization with either an alkyne or an alkene, affording an indole derivative or olefination product. The synthesis features a broad substrate scope, superior atom and step economy, as well as mild reaction conditions.
A Versatile, Traceless C-H Activation-Based Approach for the Synthesis of Heterocycles
Zhou, Shuguang,Wang, Jinhu,Zhang, Feifei,Song, Chao,Zhu, Jin
supporting information, p. 2427 - 2430 (2016/06/09)
A versatile, traceless C-H activation-based approach for the synthesis of diversified heterocycles is reported. Rh(III)-catalyzed, N-amino-directed C-H alkenylation generates either olefination products or indoles (in situ annulation) in an atom- and step-economic manner at room temperature. The remarkable reactivity endowed by this directing group enables scale-up of the reaction to a 10 g scale at a very low catalyst loading (0.01 mol %/0.1 mol %). Ex situ annulation of olefination product provides entry into an array of heterocycles.
PdII-catalyzed C-H olefination of N-(2-pyridyl)sulfonyl anilines and arylalkylamines
Garcia-Rubia, Alfonso,Urones, Beatriz,Gomez Arrayas, Ramon,Carretero, Juan C.
, p. 10927 - 10931 (2012/01/04)
Flexible friend: The N-(2-pyridyl)sulfonyl group acts as a removable directing group in the PdII-catalyzed aryl C-H ortho alkenylation of N-alkyl aniline, benzylamine, and phenethylamine derivatives with electron-poor alkenes. The products were obtained in high yields (70-90 %) and with complete regiocontrol. The mild reductive N-sulfonyl removal enables the construction of a variety of nitrogen heterocycles. EWG=electron-withdrawing group.
