1353000-31-3

Basic information

• Product Name: 2-(3-chlorophenyl)quinazoline
• Synonyms: 2-(3-chlorophenyl)quinazoline
• CAS NO: 1353000-31-3
• Molecular Weight: 240.692
• Mol File: 1353000-31-3.mol
• Article Data: 23

Chemical Properties

• CAS DataBase Reference: 2-(3-chlorophenyl)quinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-chlorophenyl)quinazoline(1353000-31-3)
• EPA Substance Registry System: 2-(3-chlorophenyl)quinazoline(1353000-31-3)

Safety Data

• Hazardous Substances Data: 1353000-31-3(Hazardous Substances Data)

Upstream product

• 501446-99-7 2-(3-chlorophenyl)-1,2,3,4-tetrahydroquinazoline 
• 587-04-2 m-Chlorobenzaldehyde 
• 4403-69-4 2-amino-1-benzylamine 
• 766-84-7 3-chloro-benzonitrile 
• 100-46-9 benzylamine 
• 5344-90-1 2-Aminobenzyl alcohol 
• 618-48-4 3-chlorobenzamide 
• 1878-65-5 3-chlorophenylacetic acid 
• 612-25-9 2-Nitrobenzyl alcohol 
• 3959-05-5 2-bromobenzylamine 
• 873-63-2 m-chlorobenzyl alcohol 
• 529-23-7 o-aminobenzaldehyde 
• 4152-90-3 m-chlorobenzylamine 

Relevant articles and documents

Efficient synthesis of quinazolines by the iron-catalyzed acceptorless dehydrogenative coupling of (2-aminophenyl)methanols and benzamides

The acceptorless dehydrogenation coupling (ADC) of (2-aminophenyl)methanols with benzamides was achieved with catalytic FeCl2·4H2O in an efficient synthesis of quinazolines. This simple catalytic system is atom-economical, environmentally benign and suited to a variety of substrates.

Ruthenium complex and preparation method thereof and catalytic application

The invention discloses a ruthenium complex and a preparation method thereof and catalytic application. The ruthenium complex is reported for the first time. Research finds that the ruthenium complexhas the activity of catalytically synthesizing quinazoline and derivatives thereof or catalytically synthesizing quinoline and derivatives thereof. When the ruthenium complex provided by the inventionis used for catalytic synthesis of quinazoline and derivatives thereof or quinoline and derivatives thereof, the ruthenium complex has the advantages of mild reaction conditions, wide substrate range, high catalytic product yield and good functional group tolerance, and is significantly superior to the prior art.

Efficient access to quinolines and quinazolines by ruthenium complexes catalyzed acceptorless dehydrogenative coupling of 2-aminoarylmethanols with ketones and nitriles

Treatment of N,N,O-tridentate pyrazolyl-pyridinyl-alcohol ligands, 2-(CR1R2OH)-6-[3,5-(R3)2C3HN2]C5H3N (R1 = R2 = Me, R3 = H (L1H); R1 = Me, R2 = Ph, R3 = H (L2H); R1 = R2 = Ph, R3 = H (L3H); R1 = R2 = R3 = Me (L4H)) with RuCl3?xH2O in refluxing EtOH afforded the corresponding Ru(III) complexes L2RuCl (1a-1d), which were well characterized by IR, HR-MS and X-ray single crystal structural determination. These Ru complexes showed similarly high catalytic performance for both dehydrogenative couplings of 2-aminoarylmethanols with ketones and nitriles, giving the quinolines and quinazolines in good to excellent yields. This protocol provides an atom-economical and sustainable route to access various structurally important quinoline and quinazoline derivatives by using phosphine-free ligand based Ru catalysts.