135328-50-6

Basic information

• Product Name: 7-(CYANOMETHOXY)INDOLE
• Synonyms: 7-(CYANOMETHOXY)INDOLE;2-((1H-Indol-7-yl)oxy)acetonitrile
• CAS NO: 135328-50-6
• Molecular Formula: C₁₀H₈N₂O
• Molecular Weight: 172.18
• Product Categories: Indoles and derivatives
• Mol File: 135328-50-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 394.521°C at 760 mmHg
• Flash Point: 192.4°C
• Appearance: /
• Density: 1.268g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 7-(CYANOMETHOXY)INDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-(CYANOMETHOXY)INDOLE(135328-50-6)
• EPA Substance Registry System: 7-(CYANOMETHOXY)INDOLE(135328-50-6)

Safety Data

• Hazardous Substances Data: 135328-50-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8N2O/c11-5-7-13-9-3-1-2-8-4-6-12-10(8)9/h1-4,6,12H,7H2

Upstream product

• 20289-27-4 7-benzyloxyindole 
• 2380-84-9 7-Indolol 
• 107-14-2 chloroacetonitrile 
• 88-75-5 2-hydroxynitrobenzene 
• 135328-49-3 7-(diphenylmethoxy)indole 
• 67810-89-3 benzhydryl-(2-nitro-phenyl)-ether 
• 590-17-0 cyanomethyl bromide 

Downstream Products

• 897402-13-0 5-(3-bromophenyl)-5-(7-cyanomethoxy-1H-indole)pentanenitrile 
• 140639-96-9 1-[3-(1,3-Dioxolan-2-yl)benzyl]-7-cyanomethoxy indole 

Relevant articles and documents

Novel approaches towards the LTD4/E4 antagonist, LY290154

Several novel approaches have been investigated for the synthesis of the LTD4/E4 antagonist LY290154. Significant improvements to the discovery route were first made by using an indoline nucleophile instead of an indolyl anion in the key substitution step. An alternative approach, introducing the 7-chloroquinoline moiety in the latest stages of the synthesis was then demonstrated. Interestingly, the pivotal intermediate of this latter route was also obtained in a one-pot process following a Katritzky methodology. Finally, an asymmetric synthesis offering significant advantages over the enantioselective route reported by McKillop was demonstrated.

N-benzyl dihydroindole LTD4 antagonists

This invention relates to pharmaceutical N-benzyl dihydroindole compounds having the general formula: STR1 and their use as LTD4 antagonists.

N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them

A compound of the formula in which R1 is hydrogen, halo, C??? alkyl, C??? alkoxy, nitrile, optionally protected carboxy, optionally protected tetrazolyl, trihalomethyl, hydroxy-C??? alkyl, aldehydo,-CH?Z,-CH=CH-Z or-CH?CH?Z where Z is optionally protected carboxy or optionally protected tetrazolyl; R2 is halo, nitrile, an optionally protected acid group or-CONR?R? where R? and R? are each hydrogen or C??? alkyl, R3 and R? are each hydrogen, C??? alkyl, optionally substituted phenyl, or C??? alkyl substituted by-CONR?R? or an optionally protected acid group; R? is where W is-CH=CH-,-CH=N-,-N=CH-,-O-or-S-, R? is hydrogen, halo, C??? alkyl, C? ?? alkoxy or trihalomethyl, and R1? is hydrogen, C? ?? alkyl, C??? alkenyl, C??? cycloalkyl or C??? alkyl-C??? cycloalkyl; R? is hydrogen or C??? alkyl; X is-O-(CH?)nCR11CR12-,-CR11R12-,-CR11R12.(CH?) n.CR13R1?-or-CR11=CR12-where R11, R12, R13 and R1? are each hydrogen or C??? alkyl, and n is 0, 1 or 2; and Y is-O-CR1?R1?-,-CR1?=CR1?-or-CR1? R1?.CR1?R1?-where R1?, R1?, R1? and R1? are each hydrogen or C??? alkyl; or a salt thereof. The compounds in unprotected form are active as leukotriene antagonists.