135338-27-1Relevant articles and documents
Dipyridyl amides: Potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists
Bonnefous, Celine,Vernier, Jean-Michel,Hutchinson, John H.,Chung, Janice,Reyes-Manalo, Grace,Kamenecka, Theodore
, p. 1197 - 1200 (2005)
The mGlu5 receptor has been implicated in a number of CNS disorders. Herein, we report on the discovery, synthesis, and biological evaluation of dipyridyl amides as small molecules mGluR5 antagonists.
Highly regioselective ring opening of quinolinic[2,3]anhydrides under mild conditions
Metobo, Sammy E.,Jabri, Salman Y.,Aktoudianakis, Evangelos,Evans, Jared,Jin, Haolun,Kim, Choung U.
, p. 6782 - 6784 (2013/11/19)
We report a study of the influence of Lewis acids upon the regioselectivity of ring opening of quinolinic[2,3]anhydrides to provide 2-(isopropoxycarbonyl)- nicotinic acids. In the presence of stoichiometric amounts of indium trifluoromethanesulfonate or lanthanum trifluoromethanesulfonate, the desired 2-position ester was generated with greater than 95:5 regioselectivity. This methodology was also applied to 6-methyl-[2,3]-quinoline to provide similar results.
NOVEL COMPOUNDS WITH A 3A-AZABICYCLO [4.1.0] HEPTANE CORE ACTING ON OREXIN RECEPTORS
-
, (2012/07/14)
This invention relates to azabicyclo[4.1.0]hept-4-yl derivatives and their use as pharmaceuticals.
