135357-96-9Relevant academic research and scientific papers
Targeted Genome Mining Reveals the Biosynthetic Gene Clusters of Natural Product CYP51 Inhibitors
Liu, Nicholas,Abramyan, Elizabeth D.,Cheng, Wei,Perlatti, Bruno,Harvey, Colin J.B.,Bills, Gerald F.,Tang, Yi
, p. 6043 - 6047 (2021)
Lanosterol 14α-demethylase (CYP51) is an important target in the development of antifungal drugs. The fungal-derived restricticin 1 and related molecules are the only examples of natural products that inhibit CYP51. Here, using colocalizations of genes en
Anti aldol reactions of α-alkoxymethyl ketones: Application to the total synthesis of (+)-restricticin
Paterson, Ian,Nowak, Thorsten
, p. 8243 - 8246 (2007/10/03)
The antifungal agent (+)-restricticin (1) was prepared in 12 steps from ketone (S)-8. The key steps are (i) the boron-mediated anti aldol reaction of (S)-8 with 9 to give 13 and (ii) the cyclisation reaction 4 → 15.
Total synthesis of restricticin
Jendrzejewski, Stefan,Ermann, Peter
, p. 615 - 618 (2007/10/02)
The novel antifungal antibiotic restriction was synthesized from L-mannose.
