185203-70-7

Upstream product

• 66222-28-4 (benzyloxymethyl)tributylstannane 
• 185203-71-8 methyl (S)-N-methyl-N-methoxy-3-(4-methoxybenzyloxy)-2-methylpropanoate 

Downstream Products

• 185203-73-0 (E)-(2S,4S,5S)-4,8-Bis-benzyloxy-5-hydroxy-1-(4-methoxy-benzyloxy)-2,6-dimethyl-oct-6-en-3-one 
• 185203-74-1 (E)-(2S,3S,4R,5S)-4,8-Bis-benzyloxy-1-(4-methoxy-benzyloxy)-2,6-dimethyl-oct-6-ene-3,5-diol 
• 185203-76-3 Trifluoro-methanesulfonic acid (E)-(2S,3S,4R,5S)-4,8-bis-benzyloxy-3,5-dihydroxy-2,6-dimethyl-oct-6-enyl ester 
• 185203-69-4 (E)-(2S,3S,4R,5S)-4,8-Bis-benzyloxy-2,6-dimethyl-oct-6-ene-1,3,5-triol 
• 185203-75-2 (2S,3R,4S,5S)-3-Benzyloxy-2-((E)-3-benzyloxy-1-methyl-propenyl)-5-methyl-tetrahydro-pyran-4-ol 
• 135357-96-9 restricticin 

Relevant academic research and scientific papers

Anti aldol reactions of α-alkoxymethyl ketones: Application to the total synthesis of (+)-restricticin

The antifungal agent (+)-restricticin (1) was prepared in 12 steps from ketone (S)-8. The key steps are (i) the boron-mediated anti aldol reaction of (S)-8 with 9 to give 13 and (ii) the cyclisation reaction 4 → 15.