135359-41-0Relevant academic research and scientific papers
An expeditious route to 1α,25-dihydroxyvitamin D3 and its analogues by an aqueous tandem palladium-catalyzed a-ring closure and suzuki coupling to the C/D unit
Gogoi, Pranjal,Sigueeiro, Rita,Eduardo, Silvina,Mourino, Antonio
supporting information; experimental part, p. 1432 - 1435 (2010/06/15)
Chemical equation presented Daily vitamins: A mild, general, and highly stereoselective Pd0-catalyzed cascade to the triene system of the hoi mone 1α,25-dihydroxyvitamin D3 and six representative analogues is reported. The intramolecular cyclization of an enol-triflate (lower fragment) followed in situ by Suzuki Miyaura coupling with an alkenyl boronic ester (upper fragment, also efficiently prepared by Pd0-catalyzed coupling) in equimolar amounts under protic conditions is ideal for the preparation of small amounts of new vitamin D analogues for biological testing (see scheme).
Functionalization of vitamin D metabolites at C-18 and application to the synthesis of 1 α, 18,25-trihydroxyvitamin D3 and 18,25-dihydroxyvitamin D3
Valles, Maria Jose,Castedo, Luis,Mourino, Antonio
, p. 1503 - 1506 (2007/10/02)
A general procedure for the introduction of a hydroxyl group at C-18 in several intermediates derived from the Inhoffen-Lythgoe diol is described for the first time. As an application, the syntheses of 1α, 18,25-trihydroxyvitamin D3 (2, dienyne
A short, flexible route to vitamin D metabolites and their side chain analogues
Mascarenas, Jose L.,Perez-Sestelo, Jose,Castedo, Luis,Mourino, Antonio
, p. 2813 - 2816 (2007/10/02)
A short, flexible approach to 25-functionalized vitamin D3 analogues including 26,27-hexadeutero-25 hydroxyvitamin D3 is described.
