1353742-17-2

Basic information

• Product Name: (3R,4S)-1-(benzyloxy)-3-((benzyloxy)methyl)-4-(benzyloxy)piperidine
• Synonyms: (3R,4S)-1-(benzyloxy)-3-((benzyloxy)methyl)-4-(benzyloxy)piperidine
• CAS NO: 1353742-17-2
• Molecular Weight: 417.548
• Mol File: 1353742-17-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (3R,4S)-1-(benzyloxy)-3-((benzyloxy)methyl)-4-(benzyloxy)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3R,4S)-1-(benzyloxy)-3-((benzyloxy)methyl)-4-(benzyloxy)piperidine(1353742-17-2)
• EPA Substance Registry System: (3R,4S)-1-(benzyloxy)-3-((benzyloxy)methyl)-4-(benzyloxy)piperidine(1353742-17-2)

Safety Data

• Hazardous Substances Data: 1353742-17-2(Hazardous Substances Data)

Upstream product

• 1353742-18-3 C₃₄H₃₆N₂O₄ 
• 3587-60-8 Benzyloxymethyl chloride 
• 39939-07-6 5-(benzyloxymethyl)cyclopentadiene 
• 110567-21-0 (1S,2R)-2-(benzyloxymethyl)-1-hydroxy-3-cyclopentene 
• 191480-69-0 (3R,4S)-4-(phenylmethoxy)-3-[(phenylmethoxy)methyl]cyclopent-1-ene 
• 1353742-14-9 4,6-di-O-benzyl-2,3-dideoxy-D-erythrohexodialdose 

Downstream Products

• 1425377-95-2 (3R,4S)-1-(benzyloxy)-3-(hydroxymethyl)piperidin-4-ol 

Relevant articles and documents

N-O bond as a glycosidic-bond surrogate: Synthetic studies toward polyhydroxylated N-alkoxypiperidines

A series of novel polyhydroxylated N-alkoxypiperidines has been synthesized by ring-closing double reductive amination (DRA) of highly functionalized 1,5-dialdehydes with various hydroxylamines. The required saccharide-based dialdehydes were prepared efficiently from sodium cyclopentadienylide in seven steps. A two-step protocol has been developed for the DRA; it led, after deprotection, to isofagomine, 3-deoxyisofagomine, and numerous other N-alkoxy analogues. The barrier to inversion in these polyhydroxylated N-alkoxypiperidine derivatives was found by variable-temperature NMR methods to be approximately 15 kcal mol-1. With the exception of N-hydroxyisofagomine itself, none of the compounds prepared showed significant inhibitory activity against sweet almond β-glucosidase. Copyright