135383-60-7

Basic information

• Product Name: (S)-2-phenyl-1-(thiazol-2-yl)ethanaMine hydrochloride
• Synonyms: (S)-2-phenyl-1-(thiazol-2-yl)ethanaMine hydrochloride;(S)-Dolaphenine hydrochloride;(R)-2-phenyl-1-(thiazol-2-yl)ethan-1-amine hydrochloride;(S)-alpha-(Phenylmethyl)-2-thiazolemethanamine monohydrochloride;(S)-2-phenyl-1-(thiazol-2-yl)ethan-1-amine hydrochloride
• CAS NO: 135383-60-7
• Molecular Formula: C₁₁H₁₂N₂S*ClH
• Molecular Weight: 240.75232
• Mol File: 135383-60-7.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (S)-2-phenyl-1-(thiazol-2-yl)ethanaMine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-phenyl-1-(thiazol-2-yl)ethanaMine hydrochloride(135383-60-7)
• EPA Substance Registry System: (S)-2-phenyl-1-(thiazol-2-yl)ethanaMine hydrochloride(135383-60-7)

Safety Data

• Hazardous Substances Data: 135383-60-7(Hazardous Substances Data)

Usage

General Description

(S)-2-phenyl-1-(thiazol-2-yl)ethanamine hydrochloride is a chemical compound that falls into the category of organosulfurs, more specifically a class of thiazoles. Thiazoles are aromatic compounds that contain both sulfur and nitrogen in a five-membered ring structure. This particular compound, with its specific configuration around the carbon atom, exhibits chirality, a property where a molecule and its mirror image are non-superimposable. The hydrochloride indicates the presence of a hydrochloric acid component. Though the specific applications and properties of this chemical are not immediately available, thiazole compounds, in general, are known for their wide range of bioactivity and utility in medicinal chemistry and drug design.

Upstream product

• 120205-64-3 (2RS,1'S)-2-<1'-((tert-butoxycarbonyl)amino)-2'-phenylethyl>-1,3-thiazolidine 
• 99281-95-5 tert-butyl [(2S)-1-amino-3-phenyl-1-thioxopropan-2-yl]carbamate 
• 88463-18-7 (S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropionamide 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 
• 72155-45-4 Boc-L-phenylalaninal 
• 120205-51-8 tert-butyl N-[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]carbamate 

Downstream Products

• 1438851-43-4 tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}-3-thioxopropyl]pyrrolidine-1-carboxylate 
• 135383-62-9 Boc-(S)-Val-(3R,4S,5S)-Dil-(2R,3R,4S)-Dap-(S)-Doe 
• 110417-88-4 dolastatin 10 
• 135383-61-8 Cbz-Dil-Dap-Doe 
• 159173-45-2 (3R,4S,5S)-Dil-(2R,3R,4S)-Dap-(S)-Doe 
• 133120-91-9 (2R,3R,4S)-dolaproine-(S)-dolaphenine 
• 120205-54-1 tert-butyl (2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-{[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino}propyl]pyrrolidine-1-carboxylate 

Relevant articles and documents

CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF

The present invention is directed to cytotoxic pentapeptides, to antibody drug conjugates thereof, and to methods for using the same to treat cancer.

An expeditious synthesis of dolastatin 10

Total synthesis of dolastatin 10 (1) was completed by developing an efficient synthesis of two key amino acid components, Dil (6) and Dap (11), and subsequent stepwise coupling of five amino acid components from C-terminal Doe.