88463-18-7

Basic information

• Product Name: Carbamic acid, [2-amino-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester
• CAS NO: 88463-18-7
• Molecular Formula: C14H20N2O3
• Molecular Weight: 264.324
• Mol File: 88463-18-7.mol
• Article Data: 52

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [2-amino-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [2-amino-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester(88463-18-7)
• EPA Substance Registry System: Carbamic acid, [2-amino-2-oxo-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester(88463-18-7)

Safety Data

• Hazardous Substances Data: 88463-18-7(Hazardous Substances Data)

Upstream product

• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 543-27-1 isobutyl chloroformate 
• 4530-18-1 2-(tert-butoxycarbonylamino)-3-phenylpropionic acid 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 73148-70-6 α(L)-aminobenzylacetonitrile 
• 21947-21-7 (S)-N-benzyloxycarbonyl-2-amino-3-phenyl-propionitrile 
• 5241-56-5 benzyl [(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]carbamate 
• 65864-22-4 (S)-2-amino-3-phenylpropionamide hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5241-58-7 L-Phenylalanine amide 
• 34619-03-9 tert-butyldicarbonate 
• 63-91-2 L-phenylalanine 
• 1336-21-6 ammonium hydroxide 

Downstream Products

• 1056904-00-7 6'-N-boc-(S)-phenylalanine-β-ICD 
• 1177408-23-9 C₂₈H₃₇N₃O₆ 
• 1177408-25-1 C₃₃H₄₆N₄O₈ 
• 930101-83-0 (S)-tert-butyl (1-cyano-2-phenylethyl)carbamate 
• 15893-46-6 di(phenylalanine) 

Relevant articles and documents

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Synthesis and structure-activity relationship of nitrile-based cruzain inhibitors incorporating a trifluoroethylamine-based P2 amide replacement

The structure-activity relationship for nitrile-based cruzain inhibitors incorporating a P2 amide replacement based on trifluoroethylamine was explored by deconstruction of a published series of inhibitors. It was demonstrated that the P3 biphenyl substituent present in the published inhibitor structures could be truncated to phenyl with only a small loss of affinity. The effects of inverting the configuration of the P2 amide replacement and linking a benzyl substituent at P1 were observed to be strongly nonadditive. We show that plotting affinity against molecular size provides a means to visualize both the molecular size efficiency of structural transformations and the nonadditivity in the structure-activity relationship. We also show how the relationship between affinity and lipophilicity, measured by high-performance liquid chromatography with an immobilized artificial membrane stationary phase, may be used to normalize affinity with respect to lipophilicity.