1353891-32-3

Upstream product

• 47235-20-1 3-(benzyl-methyl-amino)-2-methyl-1-(3-methoxy-phenyl)-propan-1-one 
• 1353891-30-1 C₈H₈O₃*C₁₉H₂₃NO₂ 
• 37951-49-8 1-(3-methoxyphenyl)propan-1-one 
• 1353891-28-7 (S)-3-(benzyl-methylamino)-2-methyl-1-(3-methoxy-phenyl)-propan-1-one 
• 925-90-6 ethylmagnesium bromide 
• 103-67-3 benzyl-methyl-amine 

Downstream Products

• 175591-09-0 tapentadol hydrochloride 
• 175591-23-8 tapentadol 
• 1353941-01-1 (2R,3R)-3-(3-methoxyphenyl)-2-methyl-pentyl-methyl-amine 

Relevant academic research and scientific papers

PROCESS FOR THE SYNTHESIS OF TAPENTADOL AND INTERMEDIATES THEREOF

The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Diagram 1, with high

NEW PROCESS FOR THE SYNTHESIS OF TAPENTADOL AND INTERMEDIATES THEREOF

The object of the present invention is a new process for the synthesis of tapentadol, both as free base and in hydrochloride form, which comprises the step of alkylation of the ketone (VII) to yield the compound (VIII), as reported in Diagram 1, with high