13539-26-9

Upstream product

• 548-77-6 tectorigenin 
• 4332-73-4 4',5,6,7-tetramethoxyisoflavone 
• 2345-17-7 4'-methoxytectorigenin 
• 114330-55-1 6-acetoxy-3-(4-acetoxy-phenyl)-5,7-dimethoxy-chromen-4-one 
• 446-72-0 5,7-Dihydroxy-3-(4-hydroxy-phenyl)-chromen-4-on 
• 642-71-7 3,4,5-trimethoxyphenol 
• 22110-04-9 6-hydroxy-2,3,4-trimethoxyphenyl p-methoxybenzyl ketone 
• 4693-91-8 4-methoxyphenyl-acetic chloride 
• 479-83-4 muningin 
• 34086-51-6 4',7-dimethoxy-5-hydroxyisoflavone 
• 13186-08-8 4H-benzopyran-4-one-5-hydroxy-6,7-dimethoxy-3-(4-methoxyphenyl) 
• 491-80-5 5,7-Dihydroxy-3-(4-methoxy-phenyl)-chromen-4-on 
• 175988-40-6 (E)-3-(4-Benzyloxy-phenyl)-1-(3,6-bis-benzyloxy-2,4-dimethoxy-phenyl)-propenone 
• 1026471-07-7 1-(3,6-Dihydroxy-2,4-dimethoxy-phenyl)-2-(4-hydroxy-phenyl)-3,3-dimethoxy-propan-1-one 

Downstream Products

• 135010-75-2 7-methoxy-5,6,4'-trihydroxyisoflavone 
• 479-83-4 muningin 
• 114330-55-1 6-acetoxy-3-(4-acetoxy-phenyl)-5,7-dimethoxy-chromen-4-one 
• 175988-51-9 6-acetoxy-3-(4-acetoxy-phenyl)-5-hydroxy-7-methoxy-chromen-4-one 

Relevant academic research and scientific papers

Formation of polyhydroxylated isoflavones from the isoflavones genistein and biochanin a by bacteria isolated from tempe

Two tempe-derived bacterial strains identified as Micrococcus or Arthrobacter species were shown to transform the 5-hydroxyisoflavones biochanin A and genistein to polyhydroxylated isoflavones by hydroxylation reactions at positions C-6 and C-8. Both strains transformed genistein to 5,6,7,4'-tetrahydroxyisoflavone and 5,7,8,4'-tetrahydroxyisoflavone and biochanin A to 4'-methoxy-5,7,8,-trihydroxyisoflavone, whereas only strain I converted biochanin A to 4'-methoxy-5,6,7-trihydroxyisoflavone. The structures of these transformation products were elucidated by spectroscopic techniques.

Synthesis, Characterization, and Antiradical Activity of 6-Hydroxygenistein

A convergent synthesis route of 6-hydroxygenistein (6-OHG) was reported, starting from cheap and readily available biochanin A, via methylation, bromination, methoxylation, and demethylation. The structure of the products was confirmed by MS, IR, 1/

α-Glucosidase inhibition of 6-hydroxyflavones. Part 3: Synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as α-glucosidase inhibitors

The SAR studies suggested that the C-ring of baicalein (1) was not necessary for the activity, and validated the importance of 2,3,4- trihydroxybenzoyl structure of 1. Thus, a series of 2,3,4-trihydroxybenzoyl- containing flavonoid analogs were investigat

Studies of the selective O-alkylation and dealkylation of flavonoids. XX. A convenient method for synthesizing 5,6,7-trihydroxyisoflavones and 5,6-dihydroxy-7-methoxyisoflavones

3′,6′-Bis(benzyloxy)-2′,4′-dimethoxychalcones, which were derived from dibenzyl ether of 3,6-dihydroxy-2,4-dimethoxyacetophenone, were oxidatively rearranged with thallium(III) nitrate (TTN) in methanol to give 2-aryl-1-[3,6-bis(benzyloxy)-2,4-dimethoxyphenyl]-3,3-dimethoxypropan-1-ones; these products were converted into 6-hydroxy-5,7-dimethoxyisoflavones by hydrogenolysis followed by cyclization. The 5-methoxy group in the acetates of the isoflavones was selectively cleaved with 5% (w/v) anhydrous aluminum bromide in acetonitrile to give quantitatively the corresponding 5-hydroxyisoflavones, which were hydrolyzed to 5,6-dihydroxy-7-methoxyisoflavones. The acetates were also demethylated to 5,6,7-trihydroxyisoflavones with 30% (w/v) anhydrous aluminum chloride in acetonitrile at 70 °C for 36-48 h. The spectral properties of these isoflavones were examined and some natural isoflavones were identified.

Isoflavones from Podocarpus amarus

The isoflavone irisolidone is a major constituent of Podocarpus amarus hearthwood.Its structure has been securely established by 13C n.m.r. studies upon a range of derivatives.The isoflavones biochanin A, genistein and daidzein are also present in the tre