13544-66-6Relevant academic research and scientific papers
13C and 1H nuclear magnetic resonance of methyl-substituted acetophenones and methyl benzoates: Steric hindrance and inhibited conjugation
Budesinsky, Milos,Kulhanek, Jiri,Boehm, Stanislav,Cigler, Petr,Exner, Otto
, p. 844 - 851 (2004)
The 1H and 13C NMR spectra of 14 methyl-substituted acetophenones and 14 methyl-substituted methyl benzoates were assigned and interpreted with respect to the conformation of the Car - C(O) bond. The substituent effects are proportional in the two series and can be divided into polar and steric: each has different effects on the 13C SCS of the individual atoms. In the case of C atoms C(O), C(1) and CH3(CO), the steric effects were quantitatively separated by comparing SCS in the ortho and para positions. The steric effects are proportional for the individual C atoms and also to steric effects estimated from other physical quantities. However, they do not depend simply on the angle of torsion φ of the functional group as anticipated hitherto. A better description distinguishes two classes of compounds: sterically not hindered or slightly hindered planar molecules and strongly sterically hindered, markedly non-planar. In order to confirm this reasoning without empirical correlations, the J(C,C) coupling constants were measured for three acetophenone derivatives labeled with 13C in the acetyl methyl group. The constants confirm unambiguously the conformation of 2-methylacetophenone; their zero values are in accord with the conformation of 2,6-dimethylacetophenone. The zero values in the unsubstituted acetophenone are at variance with previous erroneous report but all J(C,C) values are in accord with calculations at the B3LYP/6-311++G(2d,2p)// B3LYP/6-311+G(d,p) level. Copyright
Substituent Effects on Intramolecular Selectivity and Free Energy Relationships in Anodic and Metal Ion Oxidations of 5-X-1,2,3-trimethylbenzenes
Baciocchi, Enrico,Cort, Antonella Dalla,Eberson, Lennart,Mandolini, Luigi,Rol, Cesare
, p. 4544 - 4548 (2007/10/02)
Side-chain oxidations, promoted electrochemically or chemically, by cerium(IV) ammonium nitrate (CAN) or cobalt(III) acetate, of 5-substituted-1,2,3-trimethylbenzenes have been investigated, and the relative reactivity of the 2- and 1-methyl group (k
