1354552-75-2Relevant academic research and scientific papers
Stereoselective α-quaternization of 3-methoxycycloalk-2-enones via 1,4-diastereoinduction of alkoxy dienolates
Moustafa, Gamal A. I.,Kamada, Yasumasa,Tanaka, Tetsuaki,Yoshimitsu, Takehiko
, p. 1202 - 1207 (2012/03/26)
The alkylation of dienolates generated from 3-methoxycycloalk-2-enones having a 3′-hydroxyl alkenyl chain provides the corresponding quaternized cycloalkenones in a highly diastereoselective manner. The high degree of stereocontrol in the α-quaternization possibly implies intervention of a rigid chelating transition state that allows an efficient 1,4-asymmetric induction to take place.
