1354716-98-5

Basic information

• Product Name: (4S)-(4-aminophenyl)-1-(4-fluorophenyl)-(3R)-[(3S)-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one
• Synonyms: (4S)-(4-aminophenyl)-1-(4-fluorophenyl)-(3R)-[(3S)-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one
• CAS NO: 1354716-98-5
• Molecular Weight: 408.448
• Mol File: 1354716-98-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4S)-(4-aminophenyl)-1-(4-fluorophenyl)-(3R)-[(3S)-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4S)-(4-aminophenyl)-1-(4-fluorophenyl)-(3R)-[(3S)-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one(1354716-98-5)
• EPA Substance Registry System: (4S)-(4-aminophenyl)-1-(4-fluorophenyl)-(3R)-[(3S)-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one(1354716-98-5)

Safety Data

• Hazardous Substances Data: 1354716-98-5(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 371-40-4 4-fluoroaniline 
• 189028-95-3 (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidine-2-one 
• 3489-09-6 4-fluoro-N-(4-nitrobenzylidene)aniline 
• 1354716-96-3 (4S)-phenyl-3-[(5S)-(4-fluorophenyl)-(2R)-[(1S)-(4-fluorophenylamino)-1-(4-nitrophenyl)methyl]-5-hydroxypentanoyl]oxazolidin-2-one 
• 1354716-97-4 1-(4-fluorophenyl)-(3R)-[(3S)-(4-fluorophenyl)-3-trimethylsilyloxypropyl]-(4S)-(4-nitrophenyl)azetidin-2-one 

Downstream Products

• 163222-33-1 ezetemibe 

Relevant articles and documents

NEW METHOD FOR PREPARING EZETIMIBE

The present invention relates to a new method for preparing ezetimibe comprising a step of cyclizing the compound (4S)-phenyl-3-[(5S)-(4-fluorophenyl)-(2R)-[(1S)-(4-fluorophenylamino)-1-(4-nitrophenyl)methyl]-5-hydroxypentanoyl]oxazolidin-2-one or the derivatives thereof in which the hydroxyl group is protected. The invention also relates to new intermediates used in this method.