3489-09-6

Basic information

• Product Name: Benzenamine, 4-fluoro-N-[(4-nitrophenyl)methylene]-
• CAS NO: 3489-09-6
• Molecular Formula: C13H9FN2O2
• Molecular Weight: 244.225
• Mol File: 3489-09-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-fluoro-N-[(4-nitrophenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-fluoro-N-[(4-nitrophenyl)methylene]-(3489-09-6)
• EPA Substance Registry System: Benzenamine, 4-fluoro-N-[(4-nitrophenyl)methylene]-(3489-09-6)

Safety Data

• Hazardous Substances Data: 3489-09-6(Hazardous Substances Data)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 371-40-4 4-fluoroaniline 

Downstream Products

• 1354716-98-5 (4S)-(4-aminophenyl)-1-(4-fluorophenyl)-(3R)-[(3S)-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one 
• 1354716-97-4 1-(4-fluorophenyl)-(3R)-[(3S)-(4-fluorophenyl)-3-trimethylsilyloxypropyl]-(4S)-(4-nitrophenyl)azetidin-2-one 
• 1354716-96-3 (4S)-phenyl-3-[(5S)-(4-fluorophenyl)-(2R)-[(1S)-(4-fluorophenylamino)-1-(4-nitrophenyl)methyl]-5-hydroxypentanoyl]oxazolidin-2-one 
• 163222-33-1 ezetemibe 
• 111536-93-7 3-phenyl-4-(p-fluorphenyl)-5-(p-nitrophenyl)-4,5-dihydro-1,2,4-oxadiazol 

Relevant articles and documents

Observation of the complex spectra for the supramolecular system involving silver nanoparticles-biaryl Schiff bases containing the nitro group

A series of biaryl Schiff bases containing the nitro groups, 4-XArCH═NArNO2-4′ (XBANO2-4′) and 4-NO2ArCH═NArY-4′ (4-NO2BAY), were synthesized. Also, the fish sperm DNA (fsDNA) and silver nanoparticles (AgNPs) solutions were prepared. By mixing these compounds with fsDNA or AgNPs solution and determining the ultraviolet absorption spectra of the mixture solutions, an interesting phenomenon was found: a new absorption peak λmax,lim appeared in the (XBANO2-4′)-AgNPs solution, which was longer than the wavelength of λmax of XBANO2-4′ solution. The new absorption peak in the (XBANO2-4′)-AgNPs solution was the complex spectrum originating from the electron transfer between XBANO2-4′ and AgNPs. Whereas this phenomenon was not observed in the (4-NO2BAY)-AgNPs solutions, a quantitative correlation analysis was carried out with the measured spectral data, and the results show that the wave number νmax,lim of the λmax,lim is mainly affected by the excited-state substituent constant (Formula presented.) rather than the ground Hammett constant σ of the X group. The redshift magnitude Δνmax,WSL, namely, Δνmax,WSL = (1/λmax) ? (1/λmax,lim), of the wavelength λmax,lim is related to the highest occupied molecular orbital and lowest unoccupied molecular orbital of XBANO2-4′. The discovery of this new phenomenon is helpful to understanding the interaction between AgNPs-organic compound supramolecular systems.

Synthesis of N-benzyl-N-phenylthiophene-2-carboxamide analogues as a novel class of enterovirus 71 inhibitors

A series of novel human enterovirus 71 inhibitors, N-benzyl-N-phenylthiophene-2-carboxamide analogues, were synthesized and their antiviral activities were evaluated in vitro. Most derivatives of this structure against EV71 had a low micromolar range in the RD (rhabdomyosarcoma) cell lines. The most potent compound 5a, N-(4-bromobenzyl)-N-(4-fluorophenyl)thiophene-2-carboxamide, showed low micromolar activity against EV71 (EC50 = 1.42 μM) compared to the reference anti-EV71 drug enviroxime (EC50 = 0.15 μM). Preliminary SAR studies revealed that the thiophene-2-carboxamide core is crucial for maintaining antiviral activity, and N-substituent phenyl groups largely influenced the anti-EV71 efficacy of this new class of potent antiviral agents.

GREEN SYNTHESIS OF ARYL ALDIMINES USING ETHYL LACTATE

The present invention relates to a method for preparing aryl aldimines. In particular, the present invention relates to methods of preparing aryl aldimines that uses environmentally friendly solvent systems.