135508-48-4

Upstream product

• 75-15-0 carbon disulfide 
• 135508-47-3 (3R,4S)-1-benzyl-4-[(1S)-3,3-dimethyl-2,4-dioxolan-1-yl]-3-hydroxyazetidin-2-one 
• 74-88-4 methyl iodide 

Downstream Products

• 87408-18-2 (R)-1-Benzyl-4-((S)-1,2-dihydroxy-ethyl)-azetidin-2-one 
• 87408-21-7 (S)-1-Benzyl-4-(2-hydroxy-ethyl)-azetidin-2-one 
• 87408-17-1 (R)-1-Benzyl-4-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-azetidin-2-one 

Relevant academic research and scientific papers

Preparation of Chiral 3-Unsubstituted β-Lactams from 3-Hydroxy β-Lactams by Using the Alkoxyketene-Imine Cycloaddition Reaction as an Approach to the Azetidinone Ring: A Formal Synthesis of the Carbapenem Antibiotic (+)-PS-5.

Formation of chiral 3-hydroxy β-lactams from the alkoxyketene-imine cycloaddition reaction followed by deoxygenation under Barton's conditions provided a simple route to optically active 3-unsubstituted β-lactams.