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Pyridoxatin is a member of the dihydroxypyridine class, specifically 1,4-dihydroxypyridin-2-one with a 6-ethenyl-2,4-dimethylcyclohexyl substituent at position 3. It is known for its MMP-2 (Gelatinase A) inhibitory properties and exhibits antibiotic and anticancer activities. Additionally, pyridoxatin is recognized as an inhibitor of lipid peroxidation and DNA synthesis, as well as a free radical scavenger.

135529-30-5

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135529-30-5 Usage

Uses

Used in Pharmaceutical Industry:
Pyridoxatin is used as an antibiotic for its ability to inhibit bacterial growth and as an anticancer agent due to its MMP-2 (Gelatinase A) inhibitory properties. It targets and disrupts specific enzymes and pathways involved in cancer cell growth and progression, making it a potential candidate for cancer treatment.
Used in Antioxidant Applications:
Pyridoxatin is used as an antioxidant in various industries, including pharmaceuticals and cosmetics, for its free radical scavenging properties. It helps protect cells from oxidative damage caused by free radicals, which can lead to various diseases and aging.
Used in Research and Development:
Pyridoxatin is used as a research tool in the development of new drugs and therapies targeting cancer and other diseases. Its multifaceted properties, such as MMP-2 inhibition, lipid peroxidation inhibition, and DNA synthesis inhibition, make it a valuable compound for studying the underlying mechanisms of these conditions and developing targeted treatments.
Used in Cosmetics Industry:
Pyridoxatin is used as an ingredient in the cosmetics industry for its antioxidant properties. It can help protect the skin from environmental damage, such as UV radiation and pollution, and may contribute to anti-aging effects by reducing oxidative stress and promoting skin health.

Check Digit Verification of cas no

The CAS Registry Mumber 135529-30-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,5,2 and 9 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 135529-30:
(8*1)+(7*3)+(6*5)+(5*5)+(4*2)+(3*9)+(2*3)+(1*0)=125
125 % 10 = 5
So 135529-30-5 is a valid CAS Registry Number.
InChI:InChI=1/C15H21NO3/c1-4-11-8-9(2)7-10(3)13(11)14-12(17)5-6-16(19)15(14)18/h4-6,9-11,13,18-19H,1,7-8H2,2-3H3/t9-,10+,11-,13-/m0/s1

135529-30-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name pyridoxatin

1.2 Other means of identification

Product number -
Other names 3-[(1S,2R,4S,6R)-2-ethenyl-4,6-dimethylcyclohexyl]-1,4-dihydroxypyridin-2-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:135529-30-5 SDS

135529-30-5Upstream product

135529-30-5Downstream Products

135529-30-5Related news

A two-step synthesis of pyridoxatin (cas 135529-30-5) analogues08/14/2019

Condensation of 4-hydroxy-2-pyridone (4) with citronellal (10) affords o-quinone methide intermediate 11, which reacts further to give inverse electron Diels-Alder adducts 12 (46%) and 16 (25%) and ene adduct 14 (28%). Oxidation of 12 and 14 by Sammes' procedure affords pyridoxatin analogue...detailed

Lichen endophyte derived pyridoxatin (cas 135529-30-5) inactivates Candida growth by interfering with ergosterol biosynthesis08/13/2019

BackgroundThis study is to characterize the antifungal effects of pyridoxatin (PYR), a small natural product isolated from an endolichenic fungus.detailed

135529-30-5Relevant academic research and scientific papers

SHIKIMATE ANALOGUES AND METHODS OF USE

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Paragraph 0133-0134, (2017/09/08)

The present disclosure, in at least certain embodiments, is directed to shikimate (shikimic acid) analogues and compositions thereof, kits which contain the shikimate analogues or compositions thereof, and methods of use of the compounds and compositions for treating epithelial surfaces before or following exposure to irritants, allergens, and toxic agents (for example, urushiol).

Total Synthesis of (+/-)-Pyridoxatin

Snider, Barry B.,Lu, Qing

, p. 8065 - 8070 (2007/10/02)

An efficient two-step route to pyridoxatin analogues 13 and 15 has been developed.Condensation of 4-hydroxypyridone (4) with citronellal (10) affords o-quinone methide intermediate 11, which reacts further to give inverse electron demand Diels-Alder adducts 12 and 16 and ene adduct 14.Oxidation of 12 and 14 with MoO5 by Sammes' procedure completes the synthesis of 13 and 15.Using this approach, the first total synthesis of (+/-)-pyridoxatin (1) has been carried out in seven steps from cis-2,4-dimethylcyclohexanone (21).The key step is the condensation of 4-hydroxypyridone (4) with the allylic silane aldehyde 26 to give 35percent of cyclohexylpyridones 2 and 30.

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