A two-step synthesis of pyridoxatin (cas 135529-30-5) analogues
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Add time:08/14/2019 Source:sciencedirect.com
Condensation of 4-hydroxy-2-pyridone (4) with citronellal (10) affords o-quinone methide intermediate 11, which reacts further to give inverse electron Diels-Alder adducts 12 (46%) and 16 (25%) and ene adduct 14 (28%). Oxidation of 12 and 14 by Sammes' procedure affords pyridoxatin (cas 135529-30-5) analogues 13 (54%) and 15 (48%).
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