135531-92-9

Usage

Uses

Used in Pharmaceutical Industry:
1H-Indole, 5-methoxy-4-nitrois used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structural features, including the methoxy and nitro groups, can be exploited to develop new drugs with specific therapeutic properties.
Used in Organic Synthesis:
1H-Indole, 5-methoxy-4-nitroserves as a key building block in the synthesis of complex organic molecules. Its versatile structure allows for further functionalization and modification, enabling the creation of a wide range of organic compounds with diverse applications.
Used in Research and Development:
1H-Indole, 5-methoxy-4-nitrois utilized in research and development to explore its potential biological activities and applications. Its unique structure and functional groups make it an interesting candidate for studying various biological processes and developing new therapeutic agents.
Safety Considerations:
Due to the presence of a nitro group, 1H-Indole, 5-methoxy-4-nitroshould be handled with appropriate safety measures to prevent potential explosions. Proper storage, handling, and disposal protocols should be followed to ensure the safety of researchers and the environment.

Upstream product

• 186581-53-3 diazomethane 
• 135531-89-4 5-hydroxy-4-nitroindole 
• 56995-12-1 1-benzenesulfonyl-5-methoxy-1H-indole 
• 75-07-0 acetaldehyde 
• 1041752-20-8 5-methoxy-4-nitro-1-(phenylsulfonyl)-1H-indole 
• 135531-94-1 5-methoxy-4-nitroindole-3-carboxaldehyde 
• 10601-19-1 5-methoxyindole-3-carboxaldehyde 
• 5192-23-4 4-amino-1H-indole 
• 135531-95-2 5-Methoxy-4-nitro-1H-indole-3-carboxylic acid 

Downstream Products

• 4769-97-5 4-nitro-1H-indoIe 

Relevant academic research and scientific papers

Preparation method of 4-nitroindole

The invention discloses a preparation method of 4-nitroindole. The preparation method comprises the following steps: nitrating 4-methoxyphenylhydrazine hydrochloride to prepare 3-nitryl-4-methoxyphenylhydrazine hydrochloride, then enabling the 3-nitryl-4-methoxyphenylhydrazine hydrochloride to react with acetaldehyde under the catalysis of a catalyst to prepare 5-methoxyl-4-nitroindole, and finally removing methoxyl to obtain the required 4-nitroindole. The reaction process is as shown in the following figure. According to the method, a ternary catalyst system is used, so that the reaction conversion rate is high, and the selectivity is high. Furthermore, reaction conditions for the preparation method are mild, and the reaction cost is relatively low; the preparation method has relatively high industrial production prospect.

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors

1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC50 of 0.9 and 0.6 μM, respectively, exhibited

Efficient mononitration of indolic compounds with nitric acid impregnated on silica gel

The methoxyindoles (N-benzenesulfonyl and 2-carbomethoxy) were mononitrated with nitric acid adsorbed on silica gel under mild conditions to give mononitroindoles in good chemical yields.

SIMPLE SYNTHESES OF 1,3,4,5-TETRAHYDROPYRROLOQUINOLINE AND 5-HYDROXY-4-NITROINDOLE (SYNTHETIC STUDY FOR INDOLES HAVING A NITROGEN CONTAINING FUNCTIONAL GROUP AT THE 4-POSITION)

A simple four (or three) step synthesis method for 1,3,4,5-tetrahydropyrroloquinoline (6) from indole-3-carboxaldehyde (9) is developed.A single step preparation of 5-hydroxy-4-nitroindole (8) by the oxidation of 4-aminoindole (16) is also reported.