135560-62-2

Upstream product

• 133187-22-1 (2S)-2-(tert-butyldimethylsilyloxy)-2-phenylacetaldehyde 
• 4039-32-1 lithium hexamethyldisilazane 

Downstream Products

• 129687-07-6 1,2-anti-2-Amino-1-(t-butyl)dimethylsilyloxy-1-phenyl-hexane 
• 129687-05-4 1,2-anti-2-Amino-1-(t-butyl)dimethylsilyloxy-1-phenyl-4-pentene 
• 129687-05-4 1,2-syn-2-Amino-1-(t-butyl)dimethylsilyloxy-1-phenyl-4-pentene 
• 135348-17-3 (1R,2S)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethylamine 
• 135348-17-3 (1S,2S)-1-Benzyl-2-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-ethylamine 
• 135415-32-6 (1S,2R)-2-amino-1-(tert-butyldimethylsilyloxy)-1-phenylpent-4-ene 
• 135415-31-5 (S)-1-[(S)-(tert-Butyl-dimethyl-silanyloxy)-phenyl-methyl]-but-3-enylamine 

Relevant academic research and scientific papers

N-metallo imines: A new approach to α-amino alcohols from aldehydes

The addition of lithium alkyls or Grignard reagents to the in situ generated O-protected α-hydroxy-N-trimethylsilylimines proceeds in good yields and highly stereocontrolled manner to produce 1,2-aminols.

A trans-stereoselective synthesis of 3-halo-4-alkyl(aryl)-NH-azetidin-2-ones

Conrotatory ring closure of 1-halo-3-aza-4-alkyl-1,3-dienes in refluxing toluene gives rise to 3-halo-4-aryl-2-azetidinones in satisfactory yields. Dehalogenation of the resulting β-lactams by tris(trimethylsilyl)silane furnished 3-unsubstituted azetidino