1355742-75-4Relevant academic research and scientific papers
Enantioselective hydrocyanation of N-protected aldimines
Uemura, Masato,Kurono, Nobuhito,Ohkuma, Takeshi
supporting information; experimental part, p. 882 - 885 (2012/04/05)
Enantioselective hydrocyanation of N-benzyloxycarbonyl aldimines catalyzed by a Ru[(S)-phgly]2[(S)-binap]/C6H5OLi system or a bimetallic complex [Li{Ru[(S)-phgly]2[(S)-binap]}]Cl affords the amino nitriles in 92 - 99% ee. The reaction is carried out in tert-C 4H9OCH3 with a substrate-to-catalyst molar ratio in the range of 500 - 5000 at -20 to 0°C. Primary, secondary, and tertiary alkyl imines as well as the aryl and heteroaryl substrates are smoothly cyanated to produce the desired products in high yield.
