135579-88-3

Upstream product

• 99-90-1 para-bromoacetophenone 
• 7440-66-6 zinc 

Downstream Products

• 135579-93-0 1,1'-(buta-1,3-diene-2,3-diylbis(4,1-phenylene))diethanone 
• 173681-56-6 1-(4-(pyridin-2-yl)phenyl)ethanone 
• 10342-85-5 4-piperidinoacetophenone 
• 787-69-9 4,4'-diacetylbiphenyl 
• 99-93-4 4-Hydroxyacetophenone 

Relevant academic research and scientific papers

Cobalt-Catalyzed Oxidative Homocoupling of Arylzinc Species

A novel procedure for the synthesis of functionalized symmetrical biaryl compounds is described. The reaction proceeds via the oxidative homocoupling of arylzinc species formed by cobalt catalysis in the presence of air or p-benzoquinone depending on the nature of the functional group.

Cobalt-catalyzed electrophilic amination of arylzincs with N-chloroamines

Roles reversed: An efficient cobalt-catalyzed electrophilic amination of arylzinc reagents has been achieved. A variety of functionalized arylzincs and N-chloroamines were coupled under mild conditions (see scheme). Both secondary and tertiary arylamines were obtained in moderate to excellent yields. Copyright

Preparation of aromatic organozinc compounds and composition therefor

The invention relates to a technique for preparing aromatic organozinc compounds and to a composition therefore. This composition constitutes a reactant that can be used to carry out the synthesis of organozinc compounds, and comprises a cobalt salt, a zinc salt, a polar aprotic solvent and elemental zinc in divided form, the elemental zinc being in solid form, the other elements being in a form dissolved in the solvent. Application to organic synthesis.

New chemical synthesis of functionalized arylzinc compounds from aromatic or thienyl bromides under mild conditions using a simple cobalt catalyst and zinc dust

A new chemical method for the preparation of arylzinc intermediates is described in acetonitrile, on the basis of the activation of aryl bromides by low-valent cobalt species arising from the reduction of cobalt halide by zinc dust. This procedure allows for the synthesis of a variety of functionalized aryl- and thienylzinc species in good to excellent yields. The versatility and the simplicity of that original method represent an alternative to most known procedures.