Zinc, (4-acetylphenyl)bromo-

Base Information

• Chemical Name: Zinc, (4-acetylphenyl)bromo-
• CAS No.: 135579-88-3
• Molecular Formula: C8H7BrOZn
• Molecular Weight: 264.437
• Mol file: 135579-88-3.mol

Synonyms:

Chemical Property of Zinc, (4-acetylphenyl)bromo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Zinc, (4-acetylphenyl)bromo-

There total 3 articles about Zinc, (4-acetylphenyl)bromo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

para-bromoacetophenone (99-90-1) → 4,4'-diacetylbiphenyl (787-69-9) + p-BrZnPhCOCH3 (135579-88-3) + acetophenone (98-86-2)

Guidance literature:

With Ethyl 4-bromobenzoate; trifluoroacetic acid; cobalt(II) bromide; zinc; In hexanedinitrile; acetonitrile; for 0.166667 - 0.5h;

para-bromoacetophenone; With zinc dibromide; In hexanedinitrile; acetonitrile; at 20 ℃; Product distribution / selectivity;

Reference yield: 52.0%

para-bromoacetophenone (99-90-1) + zinc (7440-66-6) → 4,4'-diacetylbiphenyl (787-69-9) + p-BrZnPhCOCH3 (135579-88-3) + acetophenone (98-86-2)

Guidance literature:

With trifluoroacetic acid; cobalt(II) bromide; zinc dibromide; In acetonitrile; the mixt. in CH3CN was stirred at room temp., then arylbromide was added, stirred at room temp.; GC analysis;

DOI:10.1021/ja0289494

Reference yield:

para-bromoacetophenone (99-90-1) + zinc (7440-66-6) → p-BrZnPhCOCH3 (135579-88-3)

Guidance literature:

zinc; With 3-chloroprop-1-ene; trifluoroacetic acid; cobalt(II) bromide; In acetonitrile; at 20 ℃; for 0.05h;

para-bromoacetophenone; In acetonitrile; at 20 ℃;

DOI:10.1002/chem.201300229

upstream raw materials:

para-bromoacetophenone

zinc

Downstream raw materials:

1,1'-(buta-1,3-diene-2,3-diylbis(4,1-phenylene))diethanone

4-piperidinoacetophenone

4,4'-diacetylbiphenyl

4-Hydroxyacetophenone

Refernces

• 1、 Qian, Xin,Yu, Zailu,Auffrant, Audrey,Gosmini, Corinne. "Cobalt-catalyzed electrophilic amination of arylzincs with N-chloroamines". supporting information. p. 6225 - 6229. Retrieved 2013/07/05.
• 2、 Fillon, Hyacinthe,Gosmini, Corinne,Perichon, Jacques. "New chemical synthesis of functionalized arylzinc compounds from aromatic or thienyl bromides under mild conditions using a simple cobalt catalyst and zinc dust". . p. 3867 - 3870. Retrieved 2007/10/03.