1356037-46-1

Basic information

• Product Name: benzyl {[1-(benzyloxycarbonylamino)ethyl(methoxy)phosphoryl]oxy}acetate
• Synonyms: benzyl {[1-(benzyloxycarbonylamino)ethyl(methoxy)phosphoryl]oxy}acetate
• CAS NO: 1356037-46-1
• Molecular Weight: 421.387
• Mol File: 1356037-46-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl {[1-(benzyloxycarbonylamino)ethyl(methoxy)phosphoryl]oxy}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl {[1-(benzyloxycarbonylamino)ethyl(methoxy)phosphoryl]oxy}acetate(1356037-46-1)
• EPA Substance Registry System: benzyl {[1-(benzyloxycarbonylamino)ethyl(methoxy)phosphoryl]oxy}acetate(1356037-46-1)

Safety Data

• Hazardous Substances Data: 1356037-46-1(Hazardous Substances Data)

Upstream product

• 82629-22-9 1-(N-benzyloxycarbonylamino)ethylphosphonic acid dimethyl ester 
• 30379-58-9 benzyl glycolate 
• 107072-65-1 C₁₁H₁₅ClNO₄P 
• 65164-80-9 diphenyl 1-(phenylmethoxycarbonylamino)ethyl phosphonate 
• 61989-17-1 N-benzyloxycarbonyl-1-aminoethanephosphonic acid methyl monoester 
• 621-84-1 O-benzyl carbamate 

Relevant articles and documents

Synthesis, characterization and activity of new phosphonate dipeptides as potential inhibitors of VanX

VanX, a Zn(II)-dependent D-ala-D-ala dipeptidase, is essential for vancomycin resistance in Enterococcus faecium. The enzymatic activity of VanX was previously found to be inhibited competitively by 2-{[(1-aminoethyl) (hydroxy) phosphoryl]oxy} propanoic acid (1B). Here we report the synthesis and characterization of seven phosphonate dipeptide analogs of D-ala-D-ala with various substituent, the activity evaluation indicated that six of these phosphonate analogs inhibit VanX with IC50 of 0.48-8.21 mM. These data revealed a structure-activity relationship which is that the large substituent group on β-carbon resulted in low binding affinity of the phonphonate analog to VanX. This information will be helpful to guide the design and synthesis of the tightly-binding inhibitors for VanX.