1356187-27-3Relevant articles and documents
METHOD OF ISOLATING INGENOL
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, (2014/09/03)
The present invention relates to a new method for isolating ingenol (C20H28O5) from mixtures of diterpenoid esters and ingenol esters in a single step. Ingenol isolated by means of this method can be used as a precursor for the synthesis of biologically active ingenol derivatives, such as ingenol-3-angelate and ingenol-3-tigliate.
Semisynthesis of ingenol 3-angelate (PEP005): Efficient stereoconservative angeloylation of alcohols
Liang, Xifu,Grue-Sorensen, Gunnar,Petersen, Anders Klarskov,H?gberg, Thomas
supporting information, p. 2647 - 2652 (2013/01/15)
A high-yielding method was developed for the preparation of ingenol 3-angelate (PEP005, ingenol mebutate) via the corresponding 5,20-acetonide without concomitant isomerization of the angelate (Z-form) to the corresponding tiglate (E-form). The general sc
A METHOD OF PRODUCING INGENOL-3-ANGELATE
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, (2012/02/05)
The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Formula (I) and (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.