1356490-35-1

Basic information

• Product Name: ingenol-5,20-acetonide-3-tiglate
• CAS NO: 1356490-35-1
• Molecular Weight: 470.606
• Mol File: 1356490-35-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ingenol-5,20-acetonide-3-tiglate(CAS DataBase Reference)
• NIST Chemistry Reference: ingenol-5,20-acetonide-3-tiglate(1356490-35-1)
• EPA Substance Registry System: ingenol-5,20-acetonide-3-tiglate(1356490-35-1)

Safety Data

• Hazardous Substances Data: 1356490-35-1(Hazardous Substances Data)

Upstream product

• 565-63-9 Angelic acid 
• 77573-43-4 (6S,6aR,7aR,9R,9aS,12S,12aR,12bR)-12,12a-dihydroxy-2,2,7,7,9,11-hexamethyl-4,6,6a,7,7a,8,9,12,12a,12b-decahydro-6,9a-methanocyclopenta[9,10]cyclopropa[5,6]cyclodeca[1,2-d][1,3]dioxin-13-one 
• 35660-94-7 (Z)-2-methyl-2-butenoyl chloride 
• 80-59-1 Tiglic acid 
• 94487-74-8 (Z)-2-methyl-2-butenoic anhydride 
• 30220-46-3 ingenol 

Downstream Products

• 1356187-27-3 ingenol-3-tigliate 

Relevant articles and documents

Semisynthesis of ingenol 3-angelate (PEP005): Efficient stereoconservative angeloylation of alcohols

A high-yielding method was developed for the preparation of ingenol 3-angelate (PEP005, ingenol mebutate) via the corresponding 5,20-acetonide without concomitant isomerization of the angelate (Z-form) to the corresponding tiglate (E-form). The general sc

A METHOD OF PRODUCING INGENOL-3-ANGELATE

The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Formula (I) and (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.