135635-58-4Relevant academic research and scientific papers
Aza-Diels - Alder reaction of methyl 2-[(R)-1-phenylethyl]iminoethanoate with cyclopentadiene using practical and environmentally friendly biphasic solvent system
Hashimoto, Norio,Yasuda, Hironobu,Hayashi, Masaru,Tanabe, Yoo
, p. 105 - 109 (2005)
Aza-Diels - Alder reaction between 2-[(R)-1-phenylethyl]imino-ethanoate (1) and cyclopentadiene using the biphasic solvent system (TMSCl-CH 3OH/toluene) gave (1S,3S,4R)-2-[(R)-1-phenylethyl]-2-aza-bicyclo[2.2. 1]hept-5-ene-3-carboxylates (3a) i
KRAS G12C INHIBITORS
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Paragraph 0371, (2020/07/25)
The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
FUSED TRICYCLIC COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES
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Page/Page column 99; 100, (2011/08/04)
The present invention relates to novel Fused Tricyclic Compounds, compositions comprising at least one Fused Tricyclic Compound, and methods of using Fused Tricyclic Compounds for treating or preventing a viral infection or a virus-related disorder in a patient.
Enantio- and Diastereo-selective Synthesis of Pipecolic Acid Derivatives using the Aza-Diels-Alder Reaction of Imines with Dienes
Bailey, Patrick D.,Wilson, Robert D.,Brown, George R.
, p. 1337 - 1340 (2007/10/02)
Optically active pipecolic acid derivatives can be prepared by the aza-Diels-Alder reaction of simple dienes with the imine derived from ethyl glyoxylate and chiral 1-phenylethylamine; the cycloadditions are regiospecific, highly diastereoselective within the heterocyclic ring (>92percent exo with cyclic dienes, and 100percent endo with acyclic dienes), and lead to high asymmetric induction in most cases (average d.e. = 72percent).
Asymmetric Synthesis of Bicyclic Amino Acid Derivatives by Aza-Diels-Alder Reactions in Aqueous Solution
Waldmann, Herbert,Braun, Matthias
, p. 1045 - 1048 (2007/10/02)
Derivatives 7-10 and 13-16 of methyl and ethyl 2-azabicycloheptane-3-carboxylates are synthesized by Aza-Diels-Alder reactions of chiral iminium ions, formed in situ from glyoxylic acid and chiral amines, with cyclopentadiene.Whereas the heterodienophiles derived from phenylglycinol and esters of sterically more demanding amino acids fail to undergo asymmetric cycloadditions, with alanine methyl ester and (R)-1-phenylethylamine hydrochloride the cycloadducts are formed in yields of 15 and 52percent, respectively, reaching the values of up to 90:10 for the exo isomer. Key Words: Asymmetric synthesis / Aza-Diels-Alder reaction / Amino acids, bicyclic
