1356472-64-4

Upstream product

• 50554-93-3 4-(phenylsulfanyl)butan-1-amine 
• 1414792-75-8 (4-isothiocyanatobutyl)(phenyl)sulfane 
• 55582-10-0 2-<4-(Phenylthio)butyl>-1H-isoindole-1,3(2H)-dione 

Downstream Products

• 1356472-65-5 1,3-bis-(4-(phenylsulfinyl)-butyl)-thiourea 

Relevant academic research and scientific papers

Synthesis and biological evaluation of sulforaphane derivatives as potential antitumor agents

A series of sulforaphane derivatives were synthesized and evaluated in vitro for their cytotoxicity against five cancer cell lines (HepG2, A549, MCF-7, HCT-116 and SH-SY5Y). The pharmacological results showed that many of the derivatives displayed more potent cytotoxicity than sulforaphane (SFN). Furthermore, SFN and derivative 85 could induce cell cycle arrest at S or G2/M phase and cell apoptosis. SFN and 85 exhibited time- and dose-dependent activation on Nrf2 transcription factor, and 85 acted as a more potent Nrf2 inducer than SFN.